RNA interference (RNAi) is an antiviral pathway common to many eukaryotes that detects
and cleaves foreign nucleic acids. In mammals, mitochondrially localized proteins such as …

Multiple Mitochondrial Dysfunctions Syndrome 1 (MMDS1) is a rare, autosomal recessive
disorder caused by mutations in the NFU1 gene. NFU1 is responsible for delivery of iron …

The FOXO transcription factor, DAF‐16, plays an integral role in insulin/IGF‐1 signaling (IIS)
and stress response. In conditions of stress or decreased IIS, DAF‐16 moves to the nucleus …

Parkinson's disease resultant in the degeneration of Dopaminergic neurons and
accumulation of α-synuclein in the substantia nigra pars compacta. The synthetic …

Abstract Background In the nematode Caenorhabditis elegans, longevity in response to
germline ablation, but not in response to reduced insulin/IGF1-like signaling, is strongly …

The extrinsic diet and the intrinsic developmental programs are intertwined. Although
extensive research has been conducted on how nutrition regulates development, whether …

Abstract The inaugural Canadian Conferences on Translational Geroscience were held as
two complementary sessions in October and November 2023. The conferences explored the …

Mulberry pomace is rich in phytochemicals, but there are few studies on its utilization as a by-
product. Natural foods containing phytochemicals can alleviate the toxic effects of excessive …

Aims To investigate human breast milk (HBM) lipids that may adversely affect infant
neurodevelopment. Main methods We performed multivariate analyses that combined …

Amyotrophic lateral sclerosis (ALS) is a common adult-onset neurodegenerative disease
characterized by the progressive death of motor neurons in the cerebral cortex, brain stem …