Mitochondrial stress within the nervous system can trigger non-cell autonomous responses
in peripheral tissues. However, the specific neurons involved and their impact on organismal …

hydroxyanthranilate 3, 4-dioxygenase (HAAO) is an intermediate enzyme in the conversion
from tryptophan (TRP) to nicotinamide adenine dinucleotide (NAD+) via the kynurenine …

Reduction of insulin/insulin-like growth factor 1 (IGF1) signaling (IIS) promotes longevity
across species. In the nematode Caenorhabditis elegans, ablation of germline stem cells …

Stochastic neuronal cell fate choice involving notch-independent mechanisms is a poorly
understood biological process. The Caenorhabditis elegans AWC olfactory neuron pair …

Women are raising concerns about breast implant illness (BII), a collective term for a range
of symptoms attributed to gel bleed. To study this, Caenorhabditis elegans was exposed to …

Ageing is associated with mitochondrial dysfunction and increased oxidative stress.
Exercise generates endogenous reactive oxygen species (ROS) and promotes rapid …

The dynamicity of the mitochondrial network is crucial for meeting the ever-changing
metabolic and energy needs of the cell. Mitochondrial fission promotes the degradation and …

Mitochondrial dysfunction is a prominent hallmark of aging contributing to the functional
decline of metabolic plasticity in late life. While genetic distortions of mitochondrial integrity …

FOXO transcription factors have been shown to regulate longevity in model organisms and
are associated with longevity in humans. To gain insight into how FOXO functions to …

The gap between sequence information and experimental determination of function in
proteins is currently unsolvable. The computational and automatic implementation of …