1 Cannabinoid receptor agonists elicit analgesic effects in acute and chronic pain states via
spinal and supraspinal pathways. We investigated whether the combination of a …

Pain is more than merely nociception and response, but rather it encompasses emotional,
behavioral and cognitive components that make up the pain experience. With the recent …

The alpha2A and alpha2C adrenergic receptor (AR) subtypes mediate antinociception when
activated by the endogenous ligand norepinephrine. These receptors also produce …

Some electrophysiologic studies demonstrate new, excitatory α2-adrenoceptors on
peripheral nociceptors and their dorsal root ganglion (DRG) cell bodies after nerve injury …

Methods and devices to treat discogenic lumbar back pain are disclosed. Electrodes are
implanted within the anterior epidural space of the patient. A pulse generator that is …

Background The intravenous anesthetic etomidate exhibits structural similarities to specific
alpha2-adrenoceptor agonists of the type such as dexmedetomidine. The current study was …

Objective To compare postoperative analgesia provided by a constant rate infusion (CRI) of
dexmedetomidine (DMED) to that of a well-established positive control [morphine (MOR)] in …

Objective. Understanding the actions of opioids now encompasses pronociceptive as well
as antinociceptive mechanisms. Opioid-induced hyperalgesia (OIH) refers to increased pain …

Noradrenergic and serotonergic neurons originate in the brainstem and terminate in the
dorsal horn of the spinal cord. This monoaminergic pathway modulates the spinal …

Methods and devices to treat discogenic lumbar back pain are disclosed. Electrodes are
implanted within the anterior epidural space of the patient. A pulse generator that is …