Considerable attention has recently been paid to astrocyte functions, which are briefly
summarized. A large amount of data is available about adrenoceptor expression and …

Neuropathic pain is originated from different alterations of the nervous system. The difficulty
of treatment strongly impairs quality of life of affected people. It is associated with severe …

Agonists acting at α2‐adrenergic and opioid receptors (α2ARs and ORs, respectively) inhibit
pain transmission in the spinal cord. When coadministered, agonists activating these …

Purpose of review Migraine causes more years of life lived with disability than almost any
other condition in the world and can significantly impact the lives of individuals with …

Background Stress has paradoxical effects on pain, causing stress-induced analgesia but
also exacerbating pain via poorly understood mechanisms. Adrenergic neurotransmission is …

Dexmedetomidine is a highly selective α 2-adrenergic agonist with analgesic and sedative
properties. In the United States, the Food and Drug Administration approved the use of the …

Background: This study was designed to evaluate the effect of intravenous
dexmedetomidine infusion in patients undergoing major abdominal surgery on stress …

Alpha-2 agonists have desirable effects, including sedation, analgesia, and minimum
alveolar concentration (MAC) sparing for inhalational anesthetics, and despite profound …

Intrathecal and epidural administration of the α2-adrenergic receptor agonist clonidine in
humans results in analgesia to both acute nociceptive and chronic neuropathic pain. The …

It is well known that norepinephrine is involved in the control of pain by modulating pain‐
related responses through various pathways. α2‐Adrenergic agonists have a well …