IMPLICATIONS: The administration of IV clonidine to children anesthetized with sevoflurane
reduces the incidence of agitation at emergence. Sevoflurane is frequently used for …

Diabetic neuropathy is a common cause of chronic pain that is not adequately relieved by
conventional analgesics. The α2-adrenoceptors are involved in the regulation of …

Abstract Background. Alpha 2 (α2)-adrenoceptor agonists may be useful for their potential to
increase or prolong opioid analgesia while attenuating the development of opioid tolerance …

Monoamines and neuropeptides interact to modulate most behaviors. To better understand
these interactions, we have defined the roles of tyramine (TA), octopamine, and …

Coactivation of spinal α2-adrenergic receptors (ARs) and opioid receptors produces
antinociceptive synergy. Antinociceptive synergy between intrathecally administered α2AR …

Background Migraine affects 1 billion people worldwide and> 30 million Brazilians; besides,
it is an underdiagnosed and undertreated disorder. Objective The need to disseminate …

Background: We conducted a randomized trial to evaluate the efficacy and safety of
dexmedetomidine for prophylactic analgesia and sedation in patients with delayed …

A number of pyridazinone derivatives bearing an arylpiperazinylalkyl chain were
synthesized and tested icv in a model of acute nociception induced by thermal stimuli in …

Background Synergy between drugs manifests with increased potency and/or efficacy of the
combination relative to either agonist given alone. Synergy is typically observed between …

Background The use of alpha-2 adrenergic agonists for analgesia is limited due to a narrow
therapeutic window. Definition of the role of alpha receptor subtypes in alpha agonist …