As the genomic revolution continues to evolve, there is an increasing demand for efficient
and reliable tools for functional characterization of individual gene products. Antisense …

A series of derivatives structurally related to biphenyline (3) was designed with the aim to
modulate selectivity toward the α2-AR subtypes. The results obtained demonstrated that the …

The present study examined the possible contribution of endogenous opioids to inhibition of
spinal reflexes by an α2-adrenoceptor agonist. In rabbits decerebrated and spinalised under …

ABSTRACT Fadolmidine (MPV‐2426) is a novel α2‐adrenoceptor (α2‐AR) agonist
developed for spinal analgesia. It is highly selective for α2‐ARs, but it lacks subtype …

Gastrointestinal motility may be impaired after intestinal surgery. Epidural morphine is
effective in controlling postoperative pain, but can further reduce gastrointestinal motility …

Dex is a sedative agent that acts via a unique alpha-2 agonist mechanism. It produces
sedation while frequently preserving the ability of the patient to interact with other individuals …

Recent demonstrations of the anticonvulsant properties of agmatine suggest it may be
considered as a potential adjunct for protection against seizure. We investigated the …

The α2C-adrenergic receptor (α2CAR) is known to be poorly trafficked to the cell surface
when expressed in a variety of cell types. We tested the hypothesis that the surface …

Sickle cell anemia is a common genetic disorder in African Americans. Opioid analgesics
are traditionally the treatment for the severe pain associated with this disease. Here we …