Revisiting the neurovascular unit
S Schaeffer, C Iadecola - Nature neuroscience, 2021 - nature.com
The brain is supplied by an elaborate vascular network that originates extracranially and
reaches deep into the brain. The concept of the neurovascular unit provides a useful …
reaches deep into the brain. The concept of the neurovascular unit provides a useful …
The neurovascular unit coming of age: a journey through neurovascular coupling in health and disease
C Iadecola - Neuron, 2017 - cell.com
The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke Progress
Review Group meeting of the National Institute of Neurological Disorders and Stroke …
Review Group meeting of the National Institute of Neurological Disorders and Stroke …
Cerebral blood flow decrease as an early pathological mechanism in Alzheimer's disease
Therapies targeting late events in Alzheimer's disease (AD), including aggregation of
amyloid beta (Aβ) and hyperphosphorylated tau, have largely failed, probably because they …
amyloid beta (Aβ) and hyperphosphorylated tau, have largely failed, probably because they …
Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes
R Nortley, N Korte, P Izquierdo, C Hirunpattarasilp… - Science, 2019 - science.org
INTRODUCTION In Alzheimer's disease (AD), the production of amyloid β (Aβ) oligomers
and downstream tau dysfunction are thought to cause neuronal damage, in particular a loss …
and downstream tau dysfunction are thought to cause neuronal damage, in particular a loss …
Brain capillary pericytes exert a substantial but slow influence on blood flow
The majority of the brain's vasculature is composed of intricate capillary networks lined by
capillary pericytes. However, it remains unclear whether capillary pericytes influence blood …
capillary pericytes. However, it remains unclear whether capillary pericytes influence blood …
Neurovascular coupling and oxygenation are decreased in hippocampus compared to neocortex because of microvascular differences
The hippocampus is essential for spatial and episodic memory but is damaged early in
Alzheimer's disease and is very sensitive to hypoxia. Understanding how it regulates its …
Alzheimer's disease and is very sensitive to hypoxia. Understanding how it regulates its …
The Ca2+-gated channel TMEM16A amplifies capillary pericyte contraction and reduces cerebral blood flow after ischemia
Pericyte-mediated capillary constriction decreases cerebral blood flow in stroke after an
occluded artery is unblocked. The determinants of pericyte tone are poorly understood. We …
occluded artery is unblocked. The determinants of pericyte tone are poorly understood. We …
Brain microvascular pericytes in vascular cognitive impairment and dementia
Pericytes are unique, multi-functional mural cells localized at the abluminal side of the
perivascular space in microvessels. Originally discovered in 19th century, pericytes had …
perivascular space in microvessels. Originally discovered in 19th century, pericytes had …
The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and …
DB Kell, E Pretorius - Biochemical Journal, 2022 - portlandpress.com
Ischaemia–reperfusion (I–R) injury, initiated via bursts of reactive oxygen species produced
during the reoxygenation phase following hypoxia, is well known in a variety of acute …
during the reoxygenation phase following hypoxia, is well known in a variety of acute …
Targeting pericytes for therapeutic approaches to neurological disorders
J Cheng, N Korte, R Nortley, H Sethi, Y Tang… - Acta …, 2018 - Springer
Many central nervous system diseases currently lack effective treatment and are often
associated with defects in microvascular function, including a failure to match the energy …
associated with defects in microvascular function, including a failure to match the energy …