Biomimetic nanovesicles-based therapeutic strategy for alleviating intervertebral disc degeneration via integration with mechanically responsive miR-1249

J Guo, Y Yang, L Ni, H Cao, H Shen, Z Luo, J Niu… - Nano Today, 2024 - Elsevier
Intervertebral disc degeneration (IDD) is an important cause of disability worldwide, where
abnormal compressive loading plays a crucial role. Several microRNAs (miRNAs) have …

A prospective study of BurstDR™ spinal cord stimulation for non‐operated discogenic low back pain

MR Mons, KB Chapman, C Terwiel, EA Joosten… - Pain …, 2023 - Wiley Online Library
Introduction Chronic discogenic low back pain (CD‐LBP) is caused by degeneration of the
disc due to trauma to the annulus or by unprovoked degeneration, resulting in chronic pain …

Mitochondrial dysfunction: a new molecular mechanism of intervertebral disc degeneration

C Song, Y Xu, Q Peng, R Chen, D Zhou, K Cheng… - Inflammation …, 2023 - Springer
Objective Intervertebral disc degeneration (IVDD) is a chronic degenerative orthopedic
illness that causes lower back pain as a typical clinical symptom, severely reducing patients' …

[HTML][HTML] Major dietary patterns in relation to chronic low back pain; a cross-sectional study from RaNCD cohort

Y Pasdar, B Hamzeh, S Karimi, S Moradi, S Cheshmeh… - Nutrition journal, 2022 - Springer
Background Chronic low back pain (LBP) is the most common musculoskeletal pain that
affects a person's daily activities. This present study aimed at evaluating the relationship …

[HTML][HTML] Predictive Factors for Poor Outcome following Chemonucleolysis with Condoliase in Lumbar Disc Herniation

S Takeuchi, J Hanakita, T Takahashi, T Inoue… - Medicina, 2022 - mdpi.com
Background and Objectives: Condoliase, a chondroitin sulfate ABC endolyase, is a novel
and minimally invasive chemonucleolytic drug for lumbar disc herniation. Despite the …

[HTML][HTML] The impact of low back pain on the quality of life of children between 6 and 12 years of age

ES Santos, JM Bernardes, LS Vianna, C Ruiz-Frutos… - Healthcare, 2023 - mdpi.com
This study aimed to evaluate the impact of low back pain on the perceived health-related
quality of life of children between 6 and 12 years of age. This is a cross-sectional study of …

[HTML][HTML] An evidence based review of epidurolysis for the management of epidural adhesions

I Urits, RH Schwartz, J Brinkman, L Foster… - Psychopharmacology …, 2020 - ncbi.nlm.nih.gov
The literature concerning epidurolysis in the management of epidural adhesions is
insufficient. Prospective studies, including randomized controlled trials and observational …

[HTML][HTML] Back pain in adolescent athletes: a narrative review

N Vij, I Naron, H Tolson, A Rezayev, AD Kaye… - Orthopedic …, 2022 - ncbi.nlm.nih.gov
Background Back pain in young athletes is common. Adolescents are at an increased risk
for back pain related to several factors including rapid growth. Traditionally, the conversation …

AAAPT diagnostic criteria for acute low back pain with and without lower extremity pain

AL Nicol, MCB Adams, DB Gordon, S Mirza… - Pain …, 2020 - academic.oup.com
Objective Low back pain is one of the most common reasons for which people visit their
doctor. Between 12% and 15% of the US population seek care for spine pain each year, with …

The immediate effect of sustained natural apophyseal glide on postural stability and pain in individuals presenting with flexion-dominant chronic low back pain: A …

HM Hussein, AA Morsi… - Journal of Back and …, 2021 - content.iospress.com
BACKGROUND: Low back pain (LBP) is a common musculoskeletal problem, which
commonly affects balance. Sustained natural apophyseal glide (SNAG) is a successful …