Inhaled nitric oxide in acute respiratory distress syndrome subsets: rationale and clinical applications

S Redaelli, M Pozzi, M Giani, A Magliocca… - Journal of Aerosol …, 2023 - liebertpub.com
Acute respiratory distress syndrome (ARDS) is a life-threatening condition, characterized by
diffuse inflammatory lung injury. Since the coronavirus disease 2019 (COVID-19) pandemic …

[HTML][HTML] Inhaled nitric oxide: role in the pathophysiology of cardio-cerebrovascular and respiratory diseases

D Signori, A Magliocca, K Hayashida, JA Graw… - Intensive Care Medicine …, 2022 - Springer
Nitric oxide (NO) is a key molecule in the biology of human life. NO is involved in the
physiology of organ viability and in the pathophysiology of organ dysfunction, respectively …

Physical manoeuvres in patients with ARDS and low compliance: bedside approaches to detect lung hyperinflation and optimise mechanical ventilation

E Rezoagli, L Bastia, L Brochard… - European Respiratory …, 2023 - Eur Respiratory Soc
Mechanical ventilation in acute respiratory distress syndrome (ARDS) aims at delivering
protective tidal volume within lungs that are characterised both by collapsed and …

[HTML][HTML] Individual response in patient's effort and driving pressure to variations in assistance during pressure support ventilation

M Docci, E Rezoagli, M Teggia-Droghi… - Annals of Intensive …, 2023 - Springer
Abstract Background During Pressure Support Ventilation (PSV) an inspiratory hold allows
to measure plateau pressure (Pplat), driving pressure (∆ P), respiratory system compliance …

[HTML][HTML] A closed-loop ventilation mode that targets the lowest work and force of breathing reduces the transpulmonary driving pressure in patients with moderate-to …

LA Buiteman-Kruizinga, DMP van Meenen… - Intensive Care Medicine …, 2023 - Springer
Introduction The driving pressure (Δ P) has an independent association with outcome in
patients with acute respiratory distress syndrome (ARDS). INTELLiVENT-Adaptive Support …

[HTML][HTML] Effect of prone positioning on end-expiratory lung volume, strain and oxygenation change over time in COVID-19 acute respiratory distress syndrome: A …

O Dilken, E Rezoagli, G Yartaş Dumanlı… - Frontiers in …, 2022 - frontiersin.org
Background Prone position (PP) is a recommended intervention in severe classical acute
respiratory distress syndrome (ARDS). Changes in lung resting volume, respiratory …

[HTML][HTML] Successful Versus Failed Transition From Controlled Ventilation to Pressure Support Ventilation in COVID-19 Patients: A Retrospective Cohort Study

MP Friz, E Rezoagli, BS Fakhr, G Florio… - Critical Care …, 2024 - journals.lww.com
OBJECTIVES: In patients with COVID-19 respiratory failure, controlled mechanical
ventilation (CMV) is often necessary during the acute phases of the disease. Weaning from …

Airway closure in patients with cardiogenic pulmonary edema as a cause of driving pressure overestimation: the “uncorking effect”

M Pozzi, DR Cominesi, M Giani, L Avalli, G Foti… - Chest, 2023 - Elsevier
Airway closure is an underestimated phenomenon reported in hypoxemic respiratory failure
under mechanical ventilation, during cardiac arrest, and in patients who are obese. Because …

[HTML][HTML] Prognostic Performance of Bedside Lung Ultrasound Score (LUSS) and ROX Index in Hypoxemic Respiratory Failure Due to COVID-19

A Nova, E Rezoagli, N Eronia, A Benini… - Diagnostics, 2023 - mdpi.com
Background: Noninvasive ventilation, mainly helmet CPAP, was widely used during the
COVID-19 pandemic, even outside of intensive care units. Both the ROX index and the LUS …

[HTML][HTML] Prognostic value of oxygen saturation index trajectory phenotypes on ICU mortality in mechanically ventilated patients: a multi-database retrospective cohort …

X Shi, Y Shi, L Fan, J Yang, H Chen, K Ni… - Journal of Intensive …, 2023 - Springer
Background Heterogeneity among critically ill patients undergoing invasive mechanical
ventilation (IMV) treatment could result in high mortality rates. Currently, there are no well …