The global scale-up of antiretroviral (ARV) therapy (ART) has led to dramatic reductions in
HIV-1 mortality and incidence. However, HIV drug resistance (HIVDR) poses a potential …

SUMMARY HIV diagnostics have played a central role in the remarkable progress in
identifying, staging, initiating, and monitoring infected individuals on life-saving antiretroviral …

Background Integrase strand transfer inhibitors (INSTIs) are recommended for first-line HIV
therapy based on their relatively high genetic barrier to resistance. Although raltegravir …

Next generation sequencing (NGS) is a trending new standard for genotypic HIV-1 drug
resistance (HIVDR) testing. Many NGS HIVDR data analysis pipelines have been …

The ability of next-generation sequencing (NGS) technologies to detect low frequency HIV-1
drug resistance mutations (DRMs) not detected by dideoxynucleotide Sanger sequencing …

The increasing prevalence of acquired and transmitted HIV-1 drug resistance is an obstacle
to successful antiretroviral therapy (ART) in the low-and middle-income countries (LMICs) …

High-quality, simplified, and low-cost human immunodeficiency virus (HIV) drug resistance
tests that are able to provide timely actionable HIV resistance data at individual, population …

Background Next-generation sequencing (NGS) is gradually replacing Sanger sequencing
(SS) as the primary method for HIV genotypic resistance testing. However, there are limited …

Background Previous studies in human immunodeficiency virus (HIV)-positive individuals on
thymidine analogue backbone antiretroviral therapy (ART) with either nevirapine or …

Most patients failing antiretroviral treatment in Uganda continue to fail their treatment
regimen even if a dominant drug-resistant HIV-1 genotype is not detected. In a recent …