Initially, gene therapy was viewed as an approach for treating hereditary diseases, but its
potential role in the treatment of acquired diseases such as cancer is now widely …

Lack of targeting and improper biodistribution are major flaws in current drug-based
therapies that prevent reaching high local concentrations of the therapeutic agent. Such …

Non-viral gene therapy uses engineered nanoparticles in the virus size range for the cell-
targeted delivery of therapeutic nucleic acids. A diverse range of macromolecules are …

The construction of non-viral, virus-like vehicles for gene therapy involves the
functionalization of multipartite constructs with nucleic acid-binding, cationic agents. Short …

Cancer remains one of the leading causes of death worldwide. Although enticing, the
concept of a chemotherapeutic treatment directed towards a single target that kills tumour …

CD44 is a multifunctional cell surface protein involved in proliferation and differentiation,
angiogenesis and signaling. The expression of CD44 is up-regulated in several types of …

Despite the recognized potential of viral vectors for gene therapy, growing biological
concerns are prompting the exploration of safer, non-viral vectors to deliver therapeutic …

The therapeutic use of nucleic acids relies on the availability of sophisticated delivery
systems for targeted and intracellular delivery of these molecules. Such a gene delivery …

By recruiting functional domains supporting DNA condensation, cell binding, internalization,
endosomal escape and nuclear transport, modular single-chain polypeptides can be …

Recent developments in anti-cancer gene therapy suggest that the idea of a magic bullet for
cancer may not be a pipe dream. Viral-based anti-cancer vectors for gene therapy have …