[HTML][HTML] Biotechnological insights on the expression and production of antimicrobial peptides in plants

B Shanmugaraj, CJI Bulaon, A Malla, W Phoolcharoen - Molecules, 2021 - mdpi.com
The emergence of drug-resistant pathogens poses a serious critical threat to global public
health and requires immediate action. Antimicrobial peptides (AMPs) are a class of short …

[HTML][HTML] The antimicrobial peptide LI14 combats multidrug-resistant bacterial infections

J Shi, C Chen, D Wang, Z Wang, Y Liu - Communications Biology, 2022 - nature.com
The prevalence of multidrug-resistant (MDR) pathogens raises public fears of untreatable
infections and represents a huge health risk. There is an urgent need to exploit novel …

Structure–Activity Relationship Study of Antimicrobial Peptide PE2 Delivered Novel Linear Derivatives with Potential of Eradicating Biofilms and Low Incidence of Drug …

J Zhang, X Ouyang, F Zhang, B Li… - Journal of Medicinal …, 2023 - ACS Publications
The ongoing emergence of antibiotic-resistant pathogens had been dramatically stimulating
and accelerating the need for new drugs. PE2 is a kind of cyclic lipopeptide with broad …

Host defense peptides in nutrition and diseases: a contributor of immunology modulation

X Dou, D Yan, S Liu, N Gao, Z Ma, Z Shi… - Journal of Agricultural …, 2023 - ACS Publications
Host defense peptides (HDPs) are primary components of the innate immune system with
diverse biological functions, such as antibacterial ability and immunomodulatory function …

In Vitro Evaluation of Antimicrobial Peptides from the Black Soldier Fly (Hermetia Illucens) against a Selection of Human Pathogens

L Van Moll, J De Smet, A Paas, D Tegtmeier… - Microbiology …, 2022 - Am Soc Microbiol
Antimicrobial peptides (AMPs) are being explored as alternatives to traditional antibiotics to
combat the rising antimicrobial resistance. Insects have proven to be a valuable source of …

[HTML][HTML] Alternatives therapeutic approaches to conventional antibiotics: Advantages, limitations and potential application in medicine

H Alaoui Mdarhri, R Benmessaoud, H Yacoubi, L Seffar… - Antibiotics, 2022 - mdpi.com
Resistance to antimicrobials and particularly multidrug resistance is one of the greatest
challenges in the health system nowadays. The continual increase in the rates of …

Application of the all-hydrocarbon stapling technique in the design of membrane-active peptides

HX Luong, HTP Bui, TT Tung - Journal of Medicinal Chemistry, 2022 - ACS Publications
The threats of drug resistance and new emerging pathogens have led to an urgent need to
develop alternative treatment therapies. Recently, considerable research efforts have …

[HTML][HTML] PepVAE: variational autoencoder framework for antimicrobial peptide generation and activity prediction

SN Dean, JAE Alvarez, D Zabetakis… - Frontiers in …, 2021 - frontiersin.org
New methods for antimicrobial design are critical for combating pathogenic bacteria in the
post-antibiotic era. Fortunately, competition within complex communities has led to the …

[HTML][HTML] Lights and shadows on the therapeutic use of antimicrobial peptides

D Bellotti, M Remelli - Molecules, 2022 - mdpi.com
The emergence of antimicrobial-resistant infections is still a major concern for public health
worldwide. The number of pathogenic microorganisms capable of resisting common …

Variational autoencoder for generation of antimicrobial peptides

SN Dean, SA Walper - ACS omega, 2020 - ACS Publications
Over millennia, natural evolution has allowed for the emergence of countless biomolecules
with highly specific roles within natural systems. As seen with peptides and proteins, often …