High survival rates in adolescent cancer patients have shifted the medical focus to the long-
term outcomes of cancer treatments. Surgery, chemotherapy, and radiation increase the risk …

STUDY QUESTION Does a chemically defined maturation medium supplemented with
FGF2, LIF, and IGF1 (FLI) improve in vitro maturation (IVM) of cumulus–oocyte complexes …

Cytotoxic chemotherapies have been a mainstay of cancer treatment but are associated with
numerous systemic adverse effects, including impacts on fertility and endocrine health …

Background As advances in oncology have led to remarkable and steady improvements in
the survival rates of patients with cancer and anticancer treatment can cause premature …

Simple Summary The number of oncological patients of prepubertal and reproductive age is
increasing steeply worldwide. Not only have medical innovations and scientific advances …

BRCA1 and BRCA2 mutations are responsible for a higher incidence of breast and ovarian
cancer (from 55% up to 70% vs. 12% in the general population). If their functions have been …

Zinc (Zn) is an essential trace element with anti-inflammatory and antioxidant effects and
plays a crucial role in the female reproductive system. We aimed to investigate the protective …

In recent years, immuno-oncology has revolutionized the cancer treatment field by
harnessing the immune system's power to counteract cancer cells. While this innovative …

Premature ovarian failure (POF), a condition influenced by genetic and immune factors,
remains incurable despite years of intensive research and significant efforts. This persisting …

As more premenopausal patients undergo fertility preserving cancer treatments, there is an
increased need for fertility counseling and ovarian sparing strategies. Many patients receive …