Physiological significance of α2-adrenergic receptor subtype diversity: one receptor is not enough

M Philipp, M Brede, L Hein - American Journal of …, 2002 - journals.physiology.org
α2-Adrenergic receptors mediate part of the diverse biological effects of the endogenous
catecholamines epinephrine and norepinephrine. Three distinct subtypes of α2-adrenergic …

Dexmedetomidine enhances the local anesthetic action of lidocaine via an α-2A adrenoceptor

T Yoshitomi, A Kohjitani, S Maeda… - Anesthesia & …, 2008 - journals.lww.com
BACKGROUND: Clonidine, an α-2 adrenoceptor agonist, is a common adjunct in both
central and peripheral blocks. Dexmedetomidine, a more selective α-2 adrenoceptor …

Vascular complications in patients undergoing femoral cannulation for extracorporeal membrane oxygenation support

T Bisdas, G Beutel, G Warnecke, MM Hoeper… - The Annals of thoracic …, 2011 - Elsevier
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) is a well-established
treatment for severe cardiopulmonary failure. Patients undergoing ECMO support through …

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice

SP Heximer, RH Knutsen, X Sun… - The Journal of …, 2003 - Am Soc Clin Investig
Signaling by hormones and neurotransmitters that activate G protein–coupled receptors
(GPCRs) maintains blood pressure within the normal range despite large changes in …

Sympathetic overactivity in hypertension and cardiovascular disease

M AJ, P LE, K MS, GI - Current vascular pharmacology, 2014 - benthamdirect.com
From the first description of its anatomy by T. Willis to the novel therapeutic manipulations, it
is unanimously recognized that the sympathetic nervous system (SNS) holds a crucial role in …

α2‐Adrenergic Receptor Subtypes — Novel Functions Uncovered in Gene‐Targeted Mouse Models

M Brede, M Philipp, A Knaus, V Muthig… - Biology of the …, 2004 - Wiley Online Library
Summry—The family of adrenergic receptors contains nine different subtypes of G protein‐
coupled receptors which mediate the biological effects of adrenaline and noradrenaline …

Hemodynamic effects of dexmedetomidine in isoflurane-anesthetized cats

BH Pypendop, LS Barter, SD Stanley, JE Ilkiw - … Anaesthesia and Analgesia, 2011 - Elsevier
Objective To characterize the hemodynamic effects of dexmedetomidine in isoflurane-
anesthetized cats. Study design Prospective experimental study. Animals Six healthy adult …

[PDF][PDF] Altered neural and vascular mechanisms in hypertension

M Pintérová, J Kuneš, J Zicha - Physiol Res, 2011 - biomed.cas.cz
Essential hypertension is a multifactorial disorder which belongs to the main risk factors
responsible for renal and cardiovascular complications. This review is focused on the …

α2-Adrenergic receptor signalling in hypertension

NL Kanagy - Clinical science, 2005 - portlandpress.com
Cardiovascular regulation by the sympathetic nervous system is mediated by activation of
one or more of the nine known subtypes of the adrenergic receptor family; α1A-, α1B-, α1D …

The role of monoamines in the changes in body temperature induced by 3, 4‐methylenedioxymethamphetamine (MDMA, ecstasy) and its derivatives

JR Docherty, AR Green - British journal of pharmacology, 2010 - Wiley Online Library
Hyperthermia is probably the most widely known acute adverse event that can follow
ingestion of 3, 4‐methylenedioxymethamphetamine (MDMA, ecstasy) by recreational users …