Oral premalignant lesions (OPL) are one of the most common oral diseases, affecting the
quality of life and even leading to oral cancer. Current treatments commonly use …

Oral cancer patients report sensitivity to spicy foods and liquids. The mechanism responsible
for chemosensitivity induced by oral cancer is not known. We simulate oral cancer-induced …

This study aimed to develop an in vitro three-dimensional (3D) cell culture model of oral
carcinogenesis for the rapid, scalable testing of chemotherapeutic agents. Spheroids of …

The prognosis and survival rate of head and neck squamous cell carcinoma (HNSCC) have
remained unchanged for years, and the pathogenesis of HNSCC is still not fully understood …

Simple Summary The microbiome has been implicated in both homeostasis and disease
states, including cancer. Mechanistic investigations into the role of the microbiome in head …

Head and neck cancer is the sixth most common malignancy, and there is an urgent need to
identify physiological processes contributing to tumorigenesis. Extracellular acidification …

Head and neck squamous cell carcinoma (HNSCC) is a significant public health problem,
with a need for novel approaches to chemoprevention and treatment. Preclinical models that …

The present study describes a local drug delivery system with two functions, which can
suppress tumor growth and accelerate wound healing. Thе system consists of a two‑layer …

c-Met is a tyrosine-kinase receptor, and its aberrant activation plays critical roles in
tumorigenesis, invasion, and metastatic spread in many human tumors. PHA-665752 (PHA) …

Objectives Oral squamous cell carcinoma (OSCC) is the predominant type of oral cancer. Its
incidence is high in certain geographic regions, and it is correlated with chewing tobacco …