Obesity-associated low-grade inflammation favors weight gain, whereas systemic infection
frequently leads to anorexia. Thus, inflammatory signals can either induce positive or …

Cumulative evidence indicates that physical exercise has positive effects on cognitive
functions. Physical activity decreases the rate of cognitive decline both in healthy people …

Estrogens are important regulators of bone mass and their effects are mainly mediated via
estrogen receptor (ER) α. Central ERα exerts an inhibitory role on bone mass. ERα is highly …

Two decades of research have established that Nuclear Factor-κB (NF-κB) signaling plays a
critical role in reprogramming the fat cell transcriptome towards inflammation in response to …

Diet-induced obesity can originate from the dysregulated activity of hypothalamic neuronal
circuits, which are critical for the regulation of body weight and food intake. The exact …

Background The accumulation of visceral and ectopic fat comprise a major cause of
cardiometabolic diseases. However, novel drug targets for reducing unnecessary visceral …

Abstract Interleukin-6 (IL-6) is a major cytokine controlling not only the immune system but
also basic physiological variables such as body weight and metabolism. While central IL-6 is …

Pregnancy is associated with hyperphagia, increased adiposity and multiple
neuroendocrine adaptations. Maternal adipose tissue secretes rising amounts of interleukin …

Background/Aims: Interleukin-6 (IL-6) is a major cytokine controlling body weight and
metabolism, at least in part through actions in the central nervous system (CNS) from local …

GLP‑1 agonists such as exenatide and liraglutide are novel drugs for the treatment of
diabetes and obesity. While improvements in glycemic control can rely on an incretin effect …