Melatonin is a highly evolutionary conserved endogenous molecule that is mainly produced
by the pineal gland, but also by other nonendocrine organs, of most mammals including …

Peripheral neuropathy is a severe dose limiting toxicity associated with cancer
chemotherapy. Ever since it was identified, the clear pathological mechanisms underlying …

Pro-inflammatory systemic conditions that can cause neuroinflammation and subsequent
alterations in brain regions involved in emotional regulation have been suggested as an …

Melatonin is the major secretory product synthesized and secreted by the pineal gland and
shows both a wide distribution within phylogenetically distant organisms from bacteria to …

In Diabetes, the chronic hyperglycemia and associated complications affecting peripheral
nerves are one of the most commonly occurring microvascular complications with an overall …

Melatonin (Mel) has neuroprotective effects; however, its roles in hypoxic-ischemic brain
damage (HIBD) and the underlying mechanisms remain unknown. We aimed to explore its …

Type 2 diabetes mellitus (DM) has reached pandemic proportions and effective prevention
strategies are wanted. Its onset is accompanied by cellular distress, the nuclear factor …

The Nuclear factor-2 erythroid related factor-2 (Nrf2) is a redox regulated transcription factor
involved in the regulation of antioxidant defence systems. It drives the production of …

Peripheral nerve injury is a common clinical problem bringing heavy burden to patients, due
to its high incidence and unsatisfactory treatment. Nerve guidance conduit (NGC) is a …

Nuclear factor erythroid 2‐related factor 2 (Nrf2) is considered as the sensor of oxidative
stress, and the main aim of this signaling pathway is to maintain physiological condition by …