Diabetes mellitus poses a substantial global health challenge, necessitating innovative
approaches to improve patient outcomes. Conventional one-size-fits-all treatment strategies …

Cushing's syndrome (CS) patients have increased mortality primarily due to cardiovascular
events induced by glucocorticoid (GC) excess-related severe metabolic changes. Glucose …

Cushing's syndrome (CS) is a severe condition that results from chronic exposure to
elevated circulating cortisol levels; it is a rare but potentially life-threating condition …

Context Whether multisystem morbidity in Cushing's disease (CD) remains elevated during
long-term remission is still undetermined. Objective To investigate comorbidities in patients …

OBJECTIVE. Cushing syndrome (CS) is a constellation of clinical signs and symptoms
resulting from chronic exposure to excess cortisol, either exogenous or endogenous …

Context: Somatic mutations in PRKACA gene, encoding the catalytic subunit of protein
kinase A (PKA), have been recently found in a high proportion of sporadic adenomas …

Glucocorticoids (GC) and their cognate intracellular receptor, the glucocorticoid receptor
(GR), have been characterised as critical checkpoints in the endocrine control of energy …

Hyperadrenocorticism (HAC) and diabetes mellitus (DM) are two diseases that can occur
concurrently in dogs. The objective of this study was to evaluate the coexistence of HAC and …

Several hormones contribute to ensure penile erection, a neurovascular phenomenon in
which nitric oxide plays a major role. Erectile dysfunction (ED), which is defined as the …

Cyclic-AMP (cAMP)-dependent protein kinase (PKA) is the main effector of cAMP signaling
in all tissues. Inactivating mutations of the PRKAR1A gene, coding for the type 1A regulatory …