Principles and methods for transferring polygenic risk scores across global populations

L Kachuri, N Chatterjee, J Hirbo, DJ Schaid… - Nature Reviews …, 2024 - nature.com
Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait
or disease and may become a valuable tool for advancing precision medicine. However …

Cancer health disparities in racial/ethnic minorities in the United States

VA Zavala, PM Bracci, JM Carethers… - British journal of …, 2021 - nature.com
There are well-established disparities in cancer incidence and outcomes by race/ethnicity
that result from the interplay between structural, socioeconomic, socio-environmental …

Annual report to the nation on the status of cancer, part 1: national cancer statistics

F Islami, EM Ward, H Sung, KA Cronin… - JNCI: Journal of the …, 2021 - academic.oup.com
Abstract Background The American Cancer Society, Centers for Disease Control and
Prevention, National Cancer Institute, and North American Association of Central Cancer …

The impact of site-specific digital histology signatures on deep learning model accuracy and bias

FM Howard, J Dolezal, S Kochanny, J Schulte… - Nature …, 2021 - nature.com
Abstract The Cancer Genome Atlas (TCGA) is one of the largest biorepositories of digital
histology. Deep learning (DL) models have been trained on TCGA to predict numerous …

Cancer statistics for african Americans, 2019

CE DeSantis, KD Miller, A Goding Sauer… - CA: a cancer journal …, 2019 - Wiley Online Library
Abstract In the United States, African American/black individuals bear a disproportionate
share of the cancer burden, having the highest death rate and the lowest survival rate of any …

Epidemiology of triple-negative breast cancer: a review

FM Howard, OI Olopade - The Cancer Journal, 2021 - journals.lww.com
Triple-negative breast cancer accounted for 12% of breast cancers diagnosed in the United
States from 2012 to 2016, with a 5-year survival 8% to 16% lower than hormone receptor …

Breast cancer statistics, 2017, racial disparity in mortality by state

CE DeSantis, J Ma, A Goding Sauer… - CA: a cancer journal …, 2017 - Wiley Online Library
In this article, the American Cancer Society provides an overview of female breast cancer
statistics in the United States, including data on incidence, mortality, survival, and screening …

Breast cancer statistics, 2015: Convergence of incidence rates between black and white women

CE DeSantis, SA Fedewa… - CA: a cancer journal …, 2016 - Wiley Online Library
In this article, the American Cancer Society provides an overview of female breast cancer
statistics in the United States, including data on incidence, mortality, survival, and screening …

Cancer statistics for African Americans, 2016: Progress and opportunities in reducing racial disparities

CE DeSantis, RL Siegel, AG Sauer… - CA: a cancer journal …, 2016 - Wiley Online Library
In this article, the American Cancer Society provides the estimated number of new cancer
cases and deaths for blacks in the United States and the most recent data on cancer …

The obesity-breast cancer link: a multidisciplinary perspective

EN Devericks, MS Carson, LE McCullough… - Cancer and Metastasis …, 2022 - Springer
Obesity, exceptionally prevalent in the USA, promotes the incidence and progression of
numerous cancer types including breast cancer. Complex, interacting metabolic and …