The potential use of natural and structural analogues of antimicrobial peptides in the fight against neglected tropical diseases

A Lewies, JF Wentzel, G Jacobs, LH Du Plessis - Molecules, 2015 - mdpi.com
Recently, research into the development of new antimicrobial agents has been driven by the
increase in resistance to traditional antibiotics and Emerging Infectious Diseases …

In vivo efficacy and bioavailability of lumefantrine: Evaluating the application of Pheroid technology

LH Du Plessis, K Govender, P Denti… - European Journal of …, 2015 - Elsevier
The oral absorption of compounds with low aqueous solubility, such as lumefantrine, is
typically limited by the dissolution rate in the gastro-intestinal tract, resulting in erratic …

Improved efficacy of doxycycline in liposomes against Plasmodium falciparum in culture and Plasmodium berghei infection in mice

V Rajendran, C Singh, PC Ghosh - Canadian Journal of …, 2018 - cdnsciencepub.com
The rate at which Plasmodium falciparum is developing resistance to clinically used
antimalarial drugs is alarming. Therefore, there is a compelling need to develop an efficient …

Assessment of the Induction of Dormant Ring Stages in Plasmodium falciparum Parasites by Artemisone and Artemisone Entrapped in Pheroid Vesicles In Vitro

L Grobler, M Chavchich, RK Haynes… - Antimicrobial Agents …, 2014 - Am Soc Microbiol
The in vitro antimalarial activities of artemisone and artemisone entrapped in Pheroid
vesicles were compared, as was their ability to induce dormancy in Plasmodium falciparum …

Lipid-based Fe-and Zn-nanoformulation is more effective in alleviating Fe-and Zn-deficiency in maize

ZP Stewart, ET Paparozzi, M Djanaguiraman… - Journal of Plant …, 2019 - Taylor & Francis
Improving uptake, translocation, and utilization of foliar applied Fe and Zn is essential for
increasing biomass and grain yield under deficient conditions. We compared the effect of …

Formulation and evaluation of Pheroid vesicles containing mefloquine for the treatment of malaria

LH Du Plessis, C Helena… - Journal of Pharmacy …, 2014 - academic.oup.com
Objectives Mefloquine (MQ) is an antimalarial drug with high efficacy, often used in the
treatment and chemoprophylaxis of malaria. However, it has low solubility in water, a long …

[HTML][HTML] A toxicity profile of the Pheroid® technology in rodents

J Kleynhans, D Elgar, T Ebenhan, JR Zeevaart… - Toxicology Reports, 2019 - Elsevier
The Pheroid® drug delivery system is now on the threshold of progressing into human
clinical trials for various patented pharmaceutical applications and a systematic investigation …

In vitro evaluation of the cytotoxic, antibacterial and antioxidant properties of selected chitosan derivatives and melittin

G Jacobs - 2015 - repository.nwu.ac.za
New excipients to improve the oral absorption of drugs are developing significantly.
Polymers are used to enhance drug absorption through the gastrointestinal tract. Chitosan is …

[PDF][PDF] Dissolution of engineered iron and calcium nanocompounds and their potential for biofortification of staple crops

JTN Knijnenburg - 2015 - research-collection.ethz.ch
Background Anemia and osteoporosis are global health problems that are mainly caused by
low dietary intakes of iron and calcium. Current strategies to enhance iron and calcium …