Multiple Sclerosis (MS) is considered the most frequent inflammatory demyelinating disease
of the central nervous system (CNS). It occurs with a variable prevalence across the world. A …

A better understanding of the pathological mechanisms that drive neurodegeneration in
individuals with multiple sclerosis is needed to develop therapies that will effectively treat …

INTRODUCTION Multiple sclerosis (MS) is an inflammatory and degenerative disease of the
central nervous system (CNS) that often presents in young adults. Over the past decade …

Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple
sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 …

Multiple sclerosis (MS) is universally found to be more prevalent in women than men. This
has led to extensive studies of differences in the immune system or nervous system between …

Background: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous
system characterized by demyelination and axonal loss. The etiology of MS is unknown; …

Variation in the human leukocyte antigen (HLA) genes accounts for one-half of the genetic
risk in type 1 diabetes (T1D). Amino acid changes in the HLA-DR and HLA-DQ molecules …

CNS inflammation is a major driver of MS pathology. Differential immune responses,
including the adaptive and the innate immune system, are observed at various stages of MS …

Vitamin D system comprises hormone precursors, active metabolites, carriers, enzymes, and
receptors involved in genomic and non-genomic effects. In addition to classical bone-related …

A better understanding of immune-mediated mechanisms in the pathogenesis of multiple
sclerosis and the contribution of environmental risk factors toward the development of …