Molecular pathology of poorly differentiated and anaplastic thyroid cancer: what do pathologists need to know?

M Volante, AK Lam, M Papotti, G Tallini - Endocrine pathology, 2021 - Springer
The molecular characterization of poorly and anaplastic thyroid carcinomas has been
greatly improved in the last years following the advent of high throughput technologies …

Anaplastic thyroid carcinoma: Updates on WHO classification, clinicopathological features and staging

I Abe, K Lam - 2021 - digitum.um.es
Anaplastic thyroid carcinoma is an uncommon carcinoma representing 1 to 4% of all thyroid
cancers. The carcinoma is most common in females of the eight decades. It is a locally …

Progression of papillary thyroid carcinoma to anaplastic carcinoma in metastatic lymph nodes: solid/insular growth and hobnail cell change in lymph nodes are …

T Odate, N Oishi, M Kawai, I Tahara, K Mochizuki… - Endocrine …, 2021 - Springer
Most anaplastic thyroid carcinomas (ATCs) arise from papillary thyroid carcinoma (PTC).
This process is also called anaplastic transformation, and the morphological harbingers of …

PD-L1 expression and immune cells in anaplastic carcinoma and poorly differentiated carcinoma of the human thyroid gland: A retrospective study

S Cameselle-Garcia… - Oncology …, 2021 - spandidos-publications.com
Anaplastic thyroid carcinoma (ATC) and poorly differentiated thyroid carcinoma (PDTC)
have limited treatment options, and immune profiling may help select patients for …

Coexisting papillary and anaplastic thyroid cancer: elucidating the spectrum of aggressive behavior

JA Greenberg, MD Moore, JW Thiesmeyer… - Annals of surgical …, 2023 - Springer
Background Anaplastic thyroid carcinoma (ATC) is a rare and lethal form of thyroid cancer.
Overall prognosis is unclear when it arises focally in a background of papillary thyroid …

OVOL2 impairs RHO GTPase signaling to restrain mitosis and aggressiveness of Anaplastic Thyroid Cancer

M Gugnoni, G Manzotti, E Vitale, E Sauta… - Journal of Experimental …, 2022 - Springer
Abstract Background Anaplastic Thyroid Cancer (ATC) is an undifferentiated and aggressive
tumor that often originates from well-Differentiated Thyroid Carcinoma (DTC) through a trans …

The knockdown of Nrf2 suppressed tumor growth and increased the sensitivity to lenvatinib in anaplastic thyroid cancer

Z Gong, L Xue, M Wei, Z Liu, AC Vlantis… - Oxidative Medicine …, 2021 - Wiley Online Library
Papillary thyroid cancer can dedifferentiate into a much more aggressive form of thyroid
cancer, namely into anaplastic thyroid cancer. Nrf2 is commonly activated in papillary thyroid …

Anaplastic and poorly differentiated thyroid carcinomas: genetic evidence of high‐grade transformation from differentiated thyroid carcinoma

H Gu, J Wang, W Ran, G Li, S Hu… - The Journal of …, 2024 - Wiley Online Library
Anaplastic thyroid carcinoma (ATC) is the most advanced and aggressive thyroid cancer,
and poorly differentiated thyroid carcinoma (PDTC) lacks anaplastic histology but has lost …

Hobnail papillary thyroid carcinoma, a systematic review and meta-analysis

A Spyroglou, G Kostopoulos, S Tseleni, K Toulis… - Cancers, 2022 - mdpi.com
Simple Summary Although papillary thyroid carcinoma (PTC) has, in general, a very good
prognosis, aggressive variants of this tumor present worse clinicopathological …

Primary versus secondary anaplastic thyroid carcinoma: perspectives from multi-institutional and population-level data

TNM Ngo, TTB Le, T Le, A Bychkov, N Oishi… - Endocrine …, 2021 - Springer
Primary (or de novo) anaplastic thyroid carcinoma (ATC) is ATC without pre-existing history
of differentiated thyroid carcinoma (DTC) and no co-existing DTC foci at the time of …