Development of prefrontal cortex

SM Kolk, P Rakic - Neuropsychopharmacology, 2022 - nature.com
During evolution, the cerebral cortex advances by increasing in surface and the introduction
of new cytoarchitectonic areas among which the prefrontal cortex (PFC) is considered to be …

Genetics of human brain development

Y Zhou, H Song, G Ming - Nature Reviews Genetics, 2024 - nature.com
Brain development in humans is achieved through precise spatiotemporal genetic control,
the mechanisms of which remain largely elusive. Recently, integration of technological …

Individual human cortical progenitors can produce excitatory and inhibitory neurons

RN Delgado, DE Allen, MG Keefe, WR Mancia Leon… - Nature, 2022 - nature.com
The cerebral cortex is a cellularly complex structure comprising a rich diversity of neuronal
and glial cell types. Cortical neurons can be broadly categorized into two classes …

RNA-dependent RNA polymerase (RdRp) inhibitors: The current landscape and repurposing for the COVID-19 pandemic

L Tian, T Qiang, C Liang, X Ren, M Jia, J Zhang… - European journal of …, 2021 - Elsevier
The widespread nature of several viruses is greatly credited to their rapidly altering RNA
genomes that enable the infection to persist despite challenges presented by host cells …

Establishing cerebral organoids as models of human-specific brain evolution

AA Pollen, A Bhaduri, MG Andrews, TJ Nowakowski… - Cell, 2019 - cell.com
Direct comparisons of human and non-human primate brains can reveal molecular
pathways underlying remarkable specializations of the human brain. However, chimpanzee …

New insights into the development of the human cerebral cortex

Z Molnár, GJ Clowry, N Šestan, A Alzu'bi… - Journal of …, 2019 - Wiley Online Library
The cerebral cortex constitutes more than half the volume of the human brain and is
presumed to be responsible for the neuronal computations underlying complex phenomena …

Comparative structure and function analysis of the RIG-I-like receptors: RIG-I and MDA5

M Brisse, H Ly - Frontiers in immunology, 2019 - frontiersin.org
RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …

Evolution of the human nervous system function, structure, and development

AMM Sousa, KA Meyer, G Santpere, FO Gulden… - Cell, 2017 - cell.com
The nervous system—in particular, the brain and its cognitive abilities—is among humans'
most distinctive and impressive attributes. How the nervous system has changed in the …

Zika virus cell tropism in the developing human brain and inhibition by azithromycin

H Retallack, E Di Lullo, C Arias… - Proceedings of the …, 2016 - National Acad Sciences
The rapid spread of Zika virus (ZIKV) and its association with abnormal brain development
constitute a global health emergency. Congenital ZIKV infection produces a range of mild to …

Zika virus pathogenesis and tissue tropism

JJ Miner, MS Diamond - Cell host & microbe, 2017 - cell.com
Although Zika virus (ZIKV) was isolated approximately 70 years ago, few experimental
studies had been published prior to 2016. The recent spread of ZIKV to countries in the …