The aurora kinases in cell cycle and leukemia
B Goldenson, JD Crispino - Oncogene, 2015 - nature.com
The Aurora kinases, which include Aurora A (AURKA), Aurora B (AURKB) and Aurora C
(AURKC), are serine/threonine kinases required for the control of mitosis (AURKA and …
(AURKC), are serine/threonine kinases required for the control of mitosis (AURKA and …
GATA factor mutations in hematologic disease
JD Crispino, MS Horwitz - Blood, The Journal of the American …, 2017 - ashpublications.org
GATA family proteins play essential roles in development of many cell types, including
hematopoietic, cardiac, and endodermal lineages. The first three factors, GATAs 1, 2, and 3 …
hematopoietic, cardiac, and endodermal lineages. The first three factors, GATAs 1, 2, and 3 …
The landscape of somatic mutations in Down syndrome–related myeloid disorders
Transient abnormal myelopoiesis (TAM) is a myeloid proliferation resembling acute
megakaryoblastic leukemia (AMKL), mostly affecting perinatal infants with Down syndrome …
megakaryoblastic leukemia (AMKL), mostly affecting perinatal infants with Down syndrome …
Mechanistic insights and potential therapeutic approaches for NUP98-rearranged hematologic malignancies
NL Michmerhuizen, JM Klco… - Blood, The Journal of …, 2020 - ashpublications.org
Abstract Nucleoporin 98 (NUP98) fusion oncoproteins are observed in a spectrum of
hematologic malignancies, particularly pediatric leukemias with poor patient outcomes …
hematologic malignancies, particularly pediatric leukemias with poor patient outcomes …
[HTML][HTML] Differentiation therapy of myeloid leukemia: four decades of development
V Madan, HP Koeffler - Haematologica, 2021 - ncbi.nlm.nih.gov
Acute myeloid leukemia is characterized by arrested differentiation, and agents that
overcome this block are therapeutically useful, as shown by the efficacy of all-trans retinoic …
overcome this block are therapeutically useful, as shown by the efficacy of all-trans retinoic …
[HTML][HTML] Targeted therapies for pediatric AML: gaps and perspective
Acute myeloid leukemia (AML) is a hematopoietic disorder characterized by numerous
cytogenetic and molecular aberrations that accounts for~ 25% of childhood leukemia …
cytogenetic and molecular aberrations that accounts for~ 25% of childhood leukemia …
NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX gene expression pattern
JDE de Rooij, IHIM Hollink, S Arentsen-Peters… - Leukemia, 2013 - nature.com
Cytogenetic abnormalities and early response to treatment are the main prognostic factors in
acute myeloid leukemia (AML). Recently, NUP98/NSD1 (t (5; 11)(q35; p15)), a …
acute myeloid leukemia (AML). Recently, NUP98/NSD1 (t (5; 11)(q35; p15)), a …
CBFA2T3-GLIS2 fusion transcript is a novel common feature in pediatric, cytogenetically normal AML, not restricted to FAB M7 subtype
Pediatric cytogenetically normal acute myeloid leukemia (CN-AML) is a heterogeneous
subgroup of myeloid clonal disorders that do not harbor known mutations. To investigate the …
subgroup of myeloid clonal disorders that do not harbor known mutations. To investigate the …
Comprehensive Transcriptome Profiling of Cryptic CBFA2T3–GLIS2 Fusion–Positive AML Defines Novel Therapeutic Options: A COG and TARGET Pediatric AML …
JL Smith, RE Ries, T Hylkema, TA Alonzo… - Clinical Cancer …, 2020 - AACR
Abstract Purpose: A cryptic inv (16)(p13. 3q24. 3) encoding the CBFA2T3–GLIS2 fusion is
associated with poor outcome in infants with acute megakaryocytic leukemia. We aimed to …
associated with poor outcome in infants with acute megakaryocytic leukemia. We aimed to …
Recurrent abnormalities can be used for risk group stratification in pediatric AMKL: a retrospective intergroup study
JDE De Rooij, R Masetti… - Blood, The Journal …, 2016 - ashpublications.org
Genetic abnormalities and early treatment response are the main prognostic factors in acute
myeloid leukemia (AML). Acute megakaryoblastic leukemia (AMKL) is a rare subtype of …
myeloid leukemia (AML). Acute megakaryoblastic leukemia (AMKL) is a rare subtype of …