Many discharged COVID-19 patients affected by sequelae experience reduced quality of life
leading to an increased burden on the healthcare system, their families and society at large …

COVID-19 is a primary respiratory illness that is frequently complicated by systemic
involvement of the vasculature. Vascular involvement leads to an array of complications …

The pulmonary vasculature has been frequently overlooked in acute and chronic lung
diseases, such as acute respiratory distress syndrome (ARDS), pulmonary fibrosis (PF), and …

Leukocyte migration from the vascular compartment is critical for normal lymphocyte
recirculation in specific tissues and immune response in inflammatory locations. Leukocyte …

Background The majority of those infected by ancestral Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2) during the UK first wave (starting March 2020) did not require …

The pulmonary endothelium is a highly regulated organ that performs a wide range of
functions under physiological and pathological conditions. Since endothelial dysfunction …

Advances in omics technologies allow for holistic studies into biological systems. These
studies rely on integrative data analysis techniques to obtain a comprehensive view of the …

Severe acute respiratory disease coronavirus 2 (SARS-CoV-2) is responsible for the
coronavirus disease 2019 (COVID-19) pandemic. Although a primarily respiratory disease …

Background COVID-19 is associated with a dysregulated immune response but it is unclear
how immune dysfunction contributes to the chronic morbidity persisting in many COVID-19 …

Endothelial dysfunction accompanies the microvascular thrombosis commonly observed in
severe COVID-19. Constitutively, the endothelial surface is anticoagulant, a property …