Aquaporin-4 (AQP4) is a water channel expressed on astrocytic endfeet in the brain. The
role of AQP4 has been studied in health and in a range of pathological conditions. Interest in …

Alzheimer's disease (AD) is the primary cause of dementia and is characterized by the death
of brain cells due to the accumulation of insoluble amyloid plaques, hyperphosphorylation of …

The blood–brain barrier (BBB) is a complex vascular structure consisting of microvascular
endothelial cells that line the vessel wall, astrocyte end‐feet, pericytes, as well as the basal …

Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) are heterogeneous …

Nutritional ketosis, induced via either the classical ketogenic diet or the use of emulsified
medium-chain triglycerides, is an established treatment for pharmaceutical resistant …

The astrocytic water channel proteins aquaporin 1 (AQP1) and aquaporin 4 (AQP4) are
known to be altered in brains affected by several neurodegenerative disorders, including …

Amyotrophic lateral sclerosis (ALS) is the most prevalent neuromuscular disease worldwide.
It is a lethal and progressive neurodegenerative disease, principally affecting motor …

The aim of this article is to describe the roles of water channel proteins (WCPs) in brain
functionality. The fluid compartments of the brain, which include the brain parenchyma (with …

Astrocytes are multi-functional cells, now recognized as critical participants in many brain
functions. They play a critical physiological role in the clearance of neurotransmitters, such …

Background Amyotrophic lateral sclerosis (ALS) is a disease characterized by a progressive
degeneration of motor neurons leading to paralysis. Our previous MRI diffusion tensor …