Decades of research have disclosed a plethora of alterations in protein glycosylation that
decisively impact in all stages of disease and ultimately contribute to more aggressive cell …

Aberrant glycosylation is a key feature of malignant transformation. Hypersialylation, the
enhanced expression of sialic acid-terminated glycoconjugates on the cell surface, has …

Simple Summary Sialylation is a post-translational modification that consists in the addition
of sialic acid to growing glycan chains on glycoproteins and glycolipids. Aberrant sialylation …

Sialylation, or the covalent addition of sialic acid to the terminal end of glycoproteins, is a
biologically important modification that is involved in embryonic development …

Metastasis accounts for the majority of cancer-associated mortalities, representing a huge
health and economic burden. One of the mechanisms that enables metastasis is …

Cancer is a major cause of death in both developing and developed countries. Early
detection and efficient therapy can greatly enhance survival. Aberrant glycosylation has …

Protein glycosylation represents a nearly ubiquitous post-translational modification, and
altered glycosylation can result in clinically significant pathological consequences. Here we …

Metastatic breast cancer is currently incurable. It has recently emerged that different
metabolic pathways support metastatic breast cancer. To further uncover metabolic …

Immune checkpoint blockade has yet to produce robust anti-cancer responses for prostate
cancer. Sialyltransferases have been shown across several solid tumours, including breast …

In the past decades, the roles of carbohydrates in living organisms and their potential use in
many fields have been extensively investigated. Sialyl Lewis x (sLe x), a member of body …