Transforming growth factor-β signaling: from tissue fibrosis to therapeutic opportunities

LL Ren, XJ Li, TT Duan, ZH Li, JZ Yang… - Chemico-biological …, 2023 - Elsevier
Fibrosis refers to the excessive deposition of extracellular matrix components in the
processes of wound repair or tissue regeneration after tissue damage. Fibrosis occurs in …

Network pharmacology provides a systematic approach to understanding the treatment of ischemic heart diseases with traditional Chinese medicine

HY Yang, ML Liu, P Luo, XS Yao, H Zhou - Phytomedicine, 2022 - Elsevier
Background The field of network pharmacology showed significant development. The
concept of network pharmacology has many similarities to the philosophy of traditional …

[HTML][HTML] Inhibiting the MAPK pathway improves heart failure with preserved ejection fraction induced by salt-sensitive hypertension

S Li, Y Shi, S Yuan, J Ruan, H Pan, M Ma… - Biomedicine & …, 2024 - Elsevier
Heart failure (HF) preserved ejection fraction (HFpEF) accounts for almost 50% of HF, and
hypertension is one of the pathogenies. The MAPK signaling pathway is closely linked to …

[HTML][HTML] Research on natural products from traditional Chinese medicine in the treatment of myocardial ischemia-reperfusion injury

W Bu, Z Zhang, DKW Ocansey, Z Yu… - American Journal of …, 2022 - ncbi.nlm.nih.gov
Myocardial ischemia-reperfusion injury (MIRI) is a complicated pathologic process that
involves multiple factors including oxidative stress (free radical damage), inflammatory …

Shexiang Tongxin Dropping Pill alleviates M1 macrophage polarization-induced inflammation and endothelial dysfunction to reduce coronary microvascular …

L Cui, Y Liu, Y Hu, J Dong, Q Deng, B Jiao… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Shexiang Tongxin Dropping Pill (STDP), a
traditional Chinese medicine compound, is fragrant, invigorates the qi, unblocks pulses …

Exploring the efficacy of Shexiang Tongxin extract pills in severe heart failure

Y Zeng, W Ma, H Xue, X Ren, G Zhu, K Xiao… - Quality Assurance and …, 2023 - qascf.com
The clinical efficacy of Shexiang Tongxin pills (STP) on cardiac function, inflammation, and
prognosis was investigated in patients with severe heart failure. A total of 140 patients with …

Characterization of metabolite landscape discrimination four Bovis calculus sources by untargeted metabolomics combined with chemometric

Y Lu, J Wang, D Yu, YJ Yu, K He, L Guo, L Huang… - Microchemical …, 2024 - Elsevier
Bovis calculus has been used as a traditional Chinese medicine for more than 2000 years.
Due to Natural Bovis calculus (NBC) is expensive and rare. To meet the clinical needs, three …

Salvianolic acid C attenuates cerebral ischemic injury through inhibiting neuroinflammation via the TLR4-TREM1-NF-κB pathway

W Guo, X Xu, Y Xiao, J Zhang, P Shen, X Lu, X Fan - Chinese Medicine, 2024 - Springer
Background Stroke is a leading cause of mortality and disability with ischemic stroke being
the most common type of stroke. Salvianolic acid C (SalC), a polyphenolic compound found …

[HTML][HTML] Canagliflozin combined with aerobic exercise protects against chronic heart failure in rats

H Sun, B Du, H Fu, Z Yue, X Wang, S Yu, Z Zhang - Iscience, 2024 - cell.com
To determine the efficacy and potential protective mechanism of canagliflozin combined with
aerobic exercise in treating chronic heart failure (CHF). Isoproterenol was injected into rats …

Network Analysis and Experimental Verification of the Mechanisms of Hydroxysafflor Yellow A in Ischemic Stroke Following Atherosclerosis

X Han, H Zhou, J Yin, J Zhu, J Yang, H Wan - Molecules, 2023 - mdpi.com
Hydroxysafflor yellow A (HSYA) is derived from Carthamus tinctorius L.(Honghua in
Chinese) and is used to treat cardiovascular and cerebrovascular disease. However, the …