Therapeutic strategies to fight COVID‐19: Which is the status artis?

C Scavone, A Mascolo, C Rafaniello… - British Journal of …, 2022 - Wiley Online Library
COVID‐19 is a complex disease, and many difficulties are faced today especially in the
proper choice of pharmacological treatments. The role of antiviral agents for COVID‐19 is …

Use of antiplatelet drugs and the risk of mortality in patients with COVID-19: a meta‐analysis

CS Kow, SS Hasan - Journal of thrombosis and thrombolysis, 2021 - Springer
Globally, there have been close to 130 million reported cases of coronavirus disease 2019
(COVID-19) as of 2nd April 2021, with 2.8 million deaths documented [1]. In order to reduce …

Neutrophil-extracellular traps, cell-free DNA, and immunothrombosis in companion animals: a review

R Goggs, U Jeffery, DN LeVine… - Veterinary pathology, 2020 - journals.sagepub.com
Immunothrombosis is a potentially beneficial physiological process that aids innate immunity
and host defense against pathogen invasion. However, this process can also be damaging …

Aspirin as a potential treatment in sepsis or acute respiratory distress syndrome

P Toner, DF McAuley, M Shyamsundar - Critical care, 2015 - Springer
Sepsis is a common condition that is associated with significant morbidity, mortality and
health-care cost. Pulmonary and non-pulmonary sepsis are common causes of the acute …

Platelets and intravascular immunity: guardians of the vascular space during bloodstream infections and sepsis

B McDonald, M Dunbar - Frontiers in immunology, 2019 - frontiersin.org
Despite their humble origins as anuclear fragments of megakaryocytes, platelets have
emerged as versatile mediators of thrombosis and immunity. The diverse spectrum of …

Prevention or treatment of ARDS with aspirin: a review of preclinical models and meta-analysis of clinical studies

BA Panka, HJ de Grooth, AME Spoelstra-de Man… - Shock, 2017 - journals.lww.com
Background: The acute respiratory distress syndrome (ARDS) is a life-threating disorder that
contributes significantly to critical illness. No specific pharmacological interventions directed …

Effects of antiplatelet therapy on the mortality rate of patients with sepsis: a meta-analysis

Y Ouyang, Y Wang, B Liu, X Ma, R Ding - Journal of critical care, 2019 - Elsevier
Purpose Abnormal platelet activation plays an important role in the development of sepsis.
The effect of antiplatelet drugs on the outcome of patients with sepsis remains unclear. This …

Acute respiratory distress syndrome in acute pancreatitis

J Shah, SS Rana - Indian Journal of Gastroenterology, 2020 - Springer
Abstract Development of organ failure is one of the major determinants of mortality in
patients with acute pancreatitis (AP). Acute respiratory distress syndrome (ARDS) is an …

Clinical predictors of mortality and critical illness in patients with covid-19 pneumonia

M Basheer, E Saad, R Hagai, N Assy - Metabolites, 2021 - mdpi.com
Early identification of patients with COVID-19 who will develop severe or critical disease
symptoms is important for delivering proper and early treatment. We analyzed demographic …

[HTML][HTML] COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery

S Kumar, M Basu, P Ghosh, U Pal, MK Ghosh - Genes & Diseases, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes the complicated
disease COVID-19. Clinicians are continuously facing huge problems in the treatment of …