Allosteric modulation is a direct and effective method for regulating the function of biological
macromolecules, which play vital roles in various cellular activities. Unlike orthosteric …

Background Breast cancer stands as the most common malignancy among women globally
and a leading cause of cancer-related mortality. Conventional treatments, such as surgery …

Evodia rutaecarpa (Juss.) Benth is a traditional Chinese medicine. The active ingredient,
evodiamine, is a quinolone alkaloid and is found in Evodiae fructus. We investigated the …

Prostate cancer (PCa) is among the most commonly diagnosed solid cancers in male adults.
However, most anti-angiogenic therapies and immunotherapies fail to achieve durable …

Ulcerative colitis (UC) is a nonspecific inflammatory bowel disease characterized by
abdominal pain, bloody diarrhea, weight loss, and colon shortening. However, UC is difficult …

Evodiamine (EVO) has been demonstrated to promote apoptosis of ovarian cancer cells,
and upregulate miR‐152‐3p level in colorectal cancer. Here, we explore part of the network …

A short and expeditious total and diverted total synthesis of luotonin, vasicinone, and their
analogues has been achieved from the key tricyclic quinazolinone intermediate which was …

The heat shock protein (HSP) system is essential for the conformational stability and function
of several proteins. Therefore, the development of efficacious HSP-targeting anticancer …

In the cutting-edge era of developing precision therapeutics, nanoparticles have emerged as
a potent drug delivery system. Altering the size of poorly water-soluble drugs to nanoscale …

Evodiae Fructus (EF), an herbal medicine, possesses remarkable anti-inflammatory and
analgesic properties. It exhibits insecticidal activity as a potent insecticide candidate …