The ubiquitin proteasome system (UPS) degrades individual proteins in a highly regulated
fashion and is responsible for the degradation of misfolded, damaged, or unneeded cellular …

Drug resistance is a major obstacle in the field of pre-clinical and clinical therapeutics. The
development of novel technologies and targeted therapies have yielded new modalities to …

Proteasome is a multi-subunit protein degradation machine, which plays a key role in the
maintenance of protein homeostasis and, through degradation of regulatory proteins, in the …

Selective immunoproteasome inhibition is a promising approach for treating autoimmune
disorders, but optimal proteolytic active site subunit inhibition profiles remain unknown. We …

The immunoproteasome (iP) has been proposed to perform specialized roles in MHC class I
antigen presentation, cytokine modulation, and T cell differentiation and has emerged as a …

There is an urgent need for therapeutic interventions for desensitization and antibody-
mediated rejection (AMR) in sensitized patients with preformed or de novo donor-specific …

Trapoxin A is a microbial cyclic tetrapeptide that is an essentially irreversible inhibitor of
class I histone deacetylases (HDACs). The inhibitory warhead is the α, β-epoxyketone side …

The proteasome is a multicatalytic protease in the cytosol and nucleus of all eukaryotic cells
that controls numerous cellular processes through regulated protein degradation …

The immunoproteasome (iCP) is an isoform of the 20S proteasome that is expressed when
cells are stressed or receive an inflammatory signal. The primary role of the iCP is to …

The ubiquitin–proteasome system (UPS) is a central part of protein homeostasis, degrading
not only misfolded or oxidized proteins but also proteins with essential functions. The fact …