The immunoproteasome, a specialized form of proteasome, is mainly expressed in
lymphocytes and monocytes of jawed vertebrates and responsible for the generation of …

At the heart of the ubiquitin–proteasome system, the 20S proteasome core particle (CP)
breaks down the majority of intracellular proteins tagged for destruction. Thereby, the CP …

The ubiquitin–proteasome system (UPS) is a central part of protein homeostasis, degrading
not only misfolded or oxidized proteins but also proteins with essential functions. The fact …

The pan-proteasome inhibitor bortezomib demonstrated clinical efficacy in off-label trials of
Systemic Lupus Erythematosus. One potential mechanism of this clinical benefit is from the …

The immunoproteasome (iP) is a variant of the constitutive proteasome (cP) that is
abundantly expressed in immune cells which can also be induced in somatic cells by …

The immunoproteasome (iP), an inducible proteasome variant harboring three
immunosubunits, low molecular mass polypeptide-2 (LMP2), multicatalytic endopeptidase …

Essential core pathways of cellular biology are preserved throughout evolution, highlighting
the importance of these pathways for both bacteria and human cancer cells alike. Cell …

Cells of the immune system utilize multiple proteases to regulate cell functions and
orchestrate innate and adaptive immune responses. Dysregulated protease activities are …

Subunit-selective proteasome inhibitors are valuable tools to assess the biological and
medicinal relevance of individual proteasome active sites. Whereas the inhibitors for the …

The immunoproteasome, a specialized variant of the constitutive one, is predominantly
expressed in lymphocytes and monocytes of jawed vertebrates and is considered to be …