Calcineurin (CaN) is a unique calcium (Ca 2+) and calmodulin (CaM)-dependent
serine/threonine phosphatase that becomes activated in the presence of increased …

BACKGROUND The epidemiologic and clinical characteristics of heart transplant (HTx)
recipients during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Organ transplantation has provided another chance of survival for end-stage organ failure
patients. Yet, transplant rejection is still a main challenging factor. Immunosuppressive drugs …

A microwave biosensor based on a planar low-pass-split ring resonator is proposed for
detecting tacrolimus concentrations in solution. The biosensor was used to detect tacrolimus …

We aimed to (i) develop a population pharmacokinetic model of tacrolimus in Chinese lung
transplant recipients and (ii) propose model-based dosing regimens for individualized …

Single nucleotide polymorphisms in drug-metabolizing genes may affect tacrolimus
pharmacokinetics. Here, we investigated the influence of genotypes of CYP3A5, CYP2C19 …

Children undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are prone
to developing acute kidney injury (AKI). Markers of kidney damage: kidney injury molecule …

Nephrotoxicity is the major adverse reaction to tacrolimus; however, the underlying
mechanisms remain to be fully elucidated. Although several tacrolimus-induced …

Acute kidney injury in the context of nephrotic syndrome is a serious and alarming clinical
problem. Largely, acute kidney injury is a relatively frequent complication among patients …

We aim to describe the influence of principal ingredients of Wuzhi capsule, schisandrin A
(SIA) and schisantherin A (STA), on the pharmacokinetics of cyclosporin A (CsA) and to …