Despite many therapeutic advances leading to increasingly effective drug treatments,
thrombotic events (such as ischaemic stroke, pulmonary embolism, deep venous thrombosis …

Adherence to prescribed medication is important to the management of all diseases,
especially those of chronic nature. Drug effectiveness is substantially compromised by …

We have investigated the role of heat shock (HS) in preventing insulin resistance–induced
endothelial dysfunction. To the best of our knowledge, we report here for the first time that …

Calcium oxalate (CaOx) is the most common type of urinary stone. Increase of ROS and
NADPH oxidase gives rise to inflammation and injury of renal tubular cells, which promotes …

The renin–angiotensin system (RAS) is one of the oldest and most extensively studied
human peptide cascades, well-known for its role in regulating blood pressure. When …

Diabetic retinopathy (DR), a chronic and progressive complication of diabetes mellitus, is a
sight-threatening disease characterized in the early stages by neuronal and vascular …

CD34+ stem/progenitor cells have been identified as a promising cell population for the
autologous cell-based therapies in patients with cardiovascular disease. The counter …

Evidence indicates that angiotensin II type 2 receptors (AT2R) exert cerebroprotective
actions during stroke. A selective non-peptide AT2R agonist, Compound 21 (C21), has been …

It is well known that the renin-angiotensin system (RAS) plays a pivotal role in the
pathophysiology of cardiovascular diseases. This is well illustrated by the great success of …

Abstract Angiotensin-converting enzyme 2 (ACE2) has been recognized as a potential entry
receptor for SARS-CoV-2 infection. Binding of SARS-CoV-2 to ACE2 allows engagement …