[HTML][HTML] Urea-based anticancer agents. Exploring 100-years of research with an eye to the future
R Listro, G Rossino, F Piaggi, FF Sonekan… - Frontiers in …, 2022 - frontiersin.org
Suramin was the first urea-based drug to be approved in the clinic, and in the following
century, a number of milestone drugs based on this scaffold were developed. Indeed, urea …
century, a number of milestone drugs based on this scaffold were developed. Indeed, urea …
Pentosan Polysulfate affords pleotropic protection to multiple cells and tissues
Pentosan polysulfate (PPS), a small semi-synthetic highly sulfated heparan sulfate (HS)-like
molecule, shares many of the interactive properties of HS. The aim of this review was to …
molecule, shares many of the interactive properties of HS. The aim of this review was to …
[HTML][HTML] Suramin inhibits SARS-CoV-2 nucleocapsid phosphoprotein genome packaging function
I Boniardi, A Corona, J Basquin, C Basquin, J Milia… - Virus Research, 2023 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic is fading, however its
etiologic agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues …
etiologic agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues …
The Anti-Cancer Activity of Pentamidine and Its Derivatives (WLC-4059) Is through Blocking the Interaction between S100A1 and RAGE V Domain
The S100A1 protein in humans is a calcium-binding protein. Upon Ca2+ binding to S100A1
EF-hand motifs, the conformation of S100A1 changes and promotes interactions with target …
EF-hand motifs, the conformation of S100A1 changes and promotes interactions with target …
Developing a Fibrotic Phenotype in a 3D Human Skeletal Muscle Microphysiological System
A Ananthakumar - 2022 - search.proquest.com
Muscle fibrosis is caused by muscle injury, dystrophy, sarcopenia, and rheumatoid arthritis.
This condition is characterized by hardening and scarring, which impairs contractile muscle …
This condition is characterized by hardening and scarring, which impairs contractile muscle …