The pathogenesis of pulmonary fibrosis, including idiopathic pulmonary fibrosis (IPF) and
other forms of interstitial lung disease, involves a complex interplay of various factors …

Chronic obstructive pulmonary disease (COPD) is a common, socially significant disease
characterized by progressive airflow limitation due to chronic inflammation in the bronchi …

Rationale: MUC5AC (mucin 5AC, oligomeric gel-forming) and MUC5B (mucin 5B,
oligomeric gel-forming) are the predominant secreted polymeric mucins in mammalian …

The airway epithelium, which lines the conducting airways, is central to the defense of the
lungs against inhaled particulate matter and pathogens such as SARS-CoV-2, the virus that …

Respiratory diseases have a major impact on global health. The airway epithelium, which
acts as a frontline defence, is one of the most common targets for inhaled allergens, irritants …

Inhaled corticosteroids (ICS) are commonly prescribed first-line treatments for asthma and
chronic obstructive pulmonary disease (COPD). Recent evidence has shown that ICS use is …

The respiratory system is the primary route of infection for many contagious pathogens.
Mucociliary clearance of inhaled pathogens is an important innate defence mechanism …

Airway mucus provides an important defence against inhaled particles and pathogens [1, 2].
The essential molecules making up mucus are water (98%), salts (1%), and mucin …

Pneumonia is a worldwide threat, making discovery of novel means to combat lower
respiratory tract infection an urgent need. Manipulating the lungs' intrinsic host defenses by …

Cystic Fibrosis (CF) patients are prone to contracting bacterial lung infections with
opportunistic pathogens, especially Pseudomonas aeruginosa. Prolonged P. aeruginosa …