Although a pathogenic role for the Epstein-Barr virus (EBV) is largely undisputed for tumors
that are consistently EBV genome positive (eg, nasopharyngeal carcinoma, endemic Burkitt …

Within weeks of the first report of acquired immunodeficiency syndrome (AIDS) in 1981, it
was observed that these patients often had Kaposi sarcoma (KS), a hitherto rarely seen skin …

Hodgkin lymphoma was the first of the lymphomas to be recognized as a specific disease
entity. However, recent studies have highlighted the heterogeneity of the diseases …

The study of Hodgkin lymphoma (HL), with its unique microenvironment and long-term
follow-up, has provided exceptional insights into several areas of tumor biology. Findings in …

The advent of new technologies such as massive parallel sequencing has improved our
understanding of the genetics of classical Hodgkin lymphoma. Some of these discoveries …

Simple Summary The unique tumor composition of classical Hodgkin lymphoma (cHL), with
only a small fraction of malignant Hodgkin and Reed–Sternberg cells within the tumor tissue …

High-grade B-cell lymphomas with MYC, BCL2, and/or BCL6 rearrangements,“double-hit” or
“triple-hit” lymphomas (DTHL), are aggressive neoplasms associated with a poor prognosis …

Hodgkin lymphoma (HL) exists in two major forms, the so-called classical type (cHL) and the
nodular lymphocyte predominant type (NLPHL). Since NLPHL is considered to be an EBV …

Classic Hodgkin lymphoma (CHL) is a unique form of lymphoid cancer featuring a
heterogeneous tumor microenvironment and a relative paucity of malignant Hodgkin and …

Hodgkin's lymphoma (HL) is a lymphoid malignancy representing 5% of all cancers in
children, 16% in adolescents, and 30–40% of all malignant lymphomas and has a survival …