Biomedical application of chitosan-based nanoscale delivery systems: Potential usefulness in siRNA delivery for cancer therapy

M Ashrafizadeh, M Delfi, F Hashemi, A Zabolian… - Carbohydrate …, 2021 - Elsevier
Gene therapy is an emerging and promising strategy in cancer therapy where small
interfering RNA (siRNA) system has been deployed for down-regulation of targeted gene …

Chitosan-based colloidal polyelectrolyte complexes for drug delivery: a review

D Wu, L Zhu, Y Li, X Zhang, S Xu, G Yang… - Carbohydrate polymers, 2020 - Elsevier
Polyelectrolyte complexes (PECs) as safe drug delivery carriers, are spontaneously formed
by mixing the oppositely charged polyelectrolyte solutions in water without using organic …

[HTML][HTML] Scale-up polymeric-based nanoparticles drug delivery systems: Development and challenges

Y Herdiana, N Wathoni, S Shamsuddin, M Muchtaridi - OpenNano, 2022 - Elsevier
The development of nanotechnology as a crucial technology in recent years has resulted in
new and creative nanomedicine applications. The characteristics of nanomedicine are …

Fundamentals of siRNA and miRNA therapeutics and a review of targeted nanoparticle delivery systems in breast cancer

T Ahmadzada, G Reid, DR McKenzie - Biophysical reviews, 2018 - Springer
Gene silencing via RNA interference (RNAi) is rapidly evolving as a personalized approach
to cancer treatment. The effector molecules—small interfering RNAs (siRNAs) and …

Chemical, physical, and biological stimuli-responsive nanogels for biomedical applications (mechanisms, concepts, and advancements): A review

S Bhaladhare, S Bhattacharjee - International Journal of Biological …, 2023 - Elsevier
The development of nanotechnology has influenced the advancements in biomedical and
pharmaceutical fields. The design and formulation of stimuli-responsive nano-drug delivery …

[HTML][HTML] Chitosan nanoparticles-based cancer drug delivery: application and challenges

B Sachdeva, P Sachdeva, A Negi, S Ghosh, S Han… - Marine drugs, 2023 - mdpi.com
Chitin is the second most abundant biopolymer consisting of N-acetylglucosamine units and
is primarily derived from the shells of marine crustaceans and the cell walls of organisms …

[HTML][HTML] Delivery systems for nucleic acids and proteins: Barriers, cell capture pathways and nanocarriers

JD Torres-Vanegas, JC Cruz, LH Reyes - Pharmaceutics, 2021 - mdpi.com
Gene therapy has been used as a potential approach to address the diagnosis and
treatment of genetic diseases and inherited disorders. In this line, non-viral systems have …

[HTML][HTML] Small interfering RNA for cancer treatment: overcoming hurdles in delivery

NB Charbe, ND Amnerkar, B Ramesh… - … Pharmaceutica Sinica B, 2020 - Elsevier
In many ways, cancer cells are different from healthy cells. A lot of tactical nano-based drug
delivery systems are based on the difference between cancer and healthy cells. Currently …

Chitosan: A versatile bio-platform for breast cancer theranostics

VS Madamsetty, S Tavakol, S Moghassemi… - Journal of Controlled …, 2022 - Elsevier
Breast cancer is considered one of the utmost neoplastic diseases globally, with a high
death rate of patients. Over the last decades, many approaches have been studied to early …

[HTML][HTML] Engineering nanoparticles for targeted delivery of nucleic acid therapeutics in tumor

Y Xiao, K Shi, Y Qu, B Chu, Z Qian - Molecular Therapy-Methods & Clinical …, 2019 - cell.com
In the past 10 years, with the increase of investment in clinical nano-gene therapy, there are
many trials that have been discontinued due to poor efficacy and serious side effects …