Quinoline and quinolone dimers and their biological activities: An overview

XM Chu, C Wang, W Liu, LL Liang, KK Gong… - European journal of …, 2019 - Elsevier
Quinoline and quinolone motifs which act as structural subunits of more complex natural
products are ubiquitous in nature, and they are useful pharmacophores which play a pivotal …

Quinolone hybrids and their anti-cancer activities: An overview

F Gao, X Zhang, T Wang, J Xiao - European journal of medicinal chemistry, 2019 - Elsevier
The global pandemic of drug-sensitive cancers and the increasing threat from drug-resistant
cancers make an urgent need to develop more effective anti-cancer candidates. Quinolone …

Geminal diheteroatomic motifs: some applications of acetals, ketals, and their sulfur and nitrogen homologues in medicinal chemistry and drug design

YJ Wu, NA Meanwell - Journal of Medicinal Chemistry, 2021 - ACS Publications
Acetals and ketals and their nitrogen and sulfur homologues are often considered to be
unconventional and potentially problematic scaffolding elements or pharmacophores for the …

Comprehensive review on various strategies for antimalarial drug discovery

M Mishra, VK Mishra, V Kashaw, AK Iyer… - European journal of …, 2017 - Elsevier
The resistance of malaria parasites to existing drugs carries on growing and progressively
limiting our ability to manage this severe disease and finally lead to a massive global health …

Design and synthesis of harmiquins, harmine and chloroquine hybrids as potent antiplasmodial agents

G Poje, LP de Carvalho, J Held, D Moita… - European journal of …, 2022 - Elsevier
Malaria remains one of the major health problems worldwide. The lack of an effective
vaccine and the increasing resistance of Plasmodium to the approved antimalarial drugs …

Design, synthesis, herbicidal activity and CoMFA of aryl-formyl piperidinone HPPD inhibitors

Y Fu, M Wang, LX Zhao, SQ Zhang, YX Liu… - Pesticide Biochemistry …, 2021 - Elsevier
Isoxazole, nicotinic acid and benzoic acid are important components in many natural
products and useful synthons to build macrostructures having valuable biological activities …

New structural classes of antimalarials

GK Rathod, M Jain, KK Sharma, S Das, A Basak… - European journal of …, 2022 - Elsevier
Malaria remains a major vector borne disease claiming millions of lives worldwide due to
infections caused by Plasmodium sp. Discovery and development of antimalarial drugs have …

[图书][B] Studies in natural products chemistry

A Rahman - 2023 - books.google.com
Studies in Natural Products Chemistry, Volume 79 covers the synthesis, testing and
recording of the medicinal properties of natural products, providing cutting-edge accounts of …

Dammarane-type leads panaxadiol and protopanaxadiol for drug discovery: biological activity and structural modification

M Wang, H Li, W Liu, H Cao, X Hu, X Gao, F Xu… - European Journal of …, 2020 - Elsevier
Based on the definite therapeutic benefits, such as neuroprotective, cardioprotective,
anticancer, anti-diabetic and so on, the Panax genus which contains many valuable plants …

A quinquennial review on recent advancements and developments in search of anti-malarial agents

TM Dhameliya, D Kathuria, TM Patel… - Current Topics in …, 2023 - ingentaconnect.com
Malaria has been a major parasitic disease in tropical and subtropical regions and is
estimated to kill between one and two million people (mainly children) every year. Novel anti …