Cancer development and progression are closely associated with changes both in the
mechano-cellular phenotype of cancer and stromal cells and in the extracellular matrix …

The characterization of soft tissues remains a vital need for various bioengineering and
medical fields. Developing areas such as regenerative medicine, robot-aided surgery, and …

Atomic force microscopy (AFM) is an easy‐to‐use, powerful, high‐resolution microscope that
allows the user to image any surface and under any aqueous condition. AFM has been used …

From the first experiments of the atomic force microscopy (AFM) with biological samples, the
range of its potential applications grows extensively. One of them is the use of AFM to …

Many tumors, such as types of sarcoma and breast cancer, stiffen as they grow in a host
healthy tissue, while individual cancer cells are becoming softer. Tumor stiffening poses …

The rapidly growing field of mechanobiology demands for robust and reproducible
characterization of cell mechanical properties. Recent achievements in understanding the …

Many 3D in vitro models induce breast cancer spheroid formation; however, this alone does
not recapitulate the complex in vivo phenotype. To effectively screen therapeutics, it is …

The function of biological tissues in health and disease is regulated at cellular level and is
highly influenced by the physical microenvironment, through the interaction of forces …

Abstract Changes in the elastic properties of living tissues during normal development and
in pathological processes are often due to modifications of the collagen component of the …

Abstract Background Desmocollin-1 (DSC1) is a desmosomal transmembrane glycoprotein
that maintains cell-to-cell adhesion. DSC1 was previously associated with lymph node …