Small-molecule inhibitors, immune checkpoint inhibitors, and more: FDA-approved novel therapeutic drugs for solid tumors from 1991 to 2021

Q Wu, W Qian, X Sun, S Jiang - Journal of hematology & oncology, 2022 - Springer
Abstract The United States Food and Drug Administration (US FDA) has always been a
forerunner in drug evaluation and supervision. Over the past 31 years, 1050 drugs …

Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma

AJ Grossberg, LC Chu, CR Deig… - CA: a cancer journal …, 2020 - Wiley Online Library
Despite tremendous gains in the molecular understanding of exocrine pancreatic cancer,
the prognosis for this disease remains very poor, largely because of delayed disease …

177Lu-Dotatate plus long-acting octreotide versus high‑dose long-acting octreotide in patients with midgut neuroendocrine tumours (NETTER-1): final overall survival …

JR Strosberg, ME Caplin, PL Kunz… - The Lancet …, 2021 - thelancet.com
Background The primary analysis of the phase 3 NETTER-1 trial showed significant
improvement in progression-free survival with 177 Lu-Dotatate plus long-acting octreotide …

Epidemiology, incidence, and prevalence of neuroendocrine neoplasms: are there global differences?

S Das, A Dasari - Current oncology reports, 2021 - Springer
Abstract Purpose of Review The purpose of our review is to explore global epidemiologic
trends of gastroenteropancreatic (GEP) neuroendocrine tumors (NETs). Specifically, we …

Epidemiologic trends of and factors associated with overall survival for patients with gastroenteropancreatic neuroendocrine tumors in the United States

Z Xu, L Wang, S Dai, M Chen, F Li, J Sun… - JAMA network …, 2021 - jamanetwork.com
Importance Although the incidence and prevalence of gastroenteropancreatic
neuroendocrine tumors (GEP-NETs) have been thought to have increased during the past …

[HTML][HTML] Gastrointestinal neuroendocrine tumors in 2020

M Ahmed - World journal of gastrointestinal oncology, 2020 - ncbi.nlm.nih.gov
Gastrointestinal neuroendocrine tumors are rare slow-growing tumors with distinct
histological, biological, and clinical characteristics that have increased in incidence and …

[HTML][HTML] Pancreas—its functions, disorders, and physiological impact on the mammals' organism

M Karpińska, M Czauderna - Frontiers in physiology, 2022 - frontiersin.org
This review aimed to analyze the scientific literature on pancreatic diseases (especially
exocrine pancreatic insufficiency). This review also describes the correlation between the …

Update on epidemiology, diagnosis, and biomarkers in gastroenteropancreatic neuroendocrine neoplasms

D Takayanagi, H Cho, E Machida, A Kawamura… - Cancers, 2022 - mdpi.com
Simple Summary Neuroendocrine neoplasms are divided into two groups: well-
differentiated neuroendocrine tumors and poorly differentiated neuroendocrine carcinomas …

Critical updates in neuroendocrine tumors: Version 9 American Joint Committee on Cancer staging system for gastroenteropancreatic neuroendocrine tumors

A Chauhan, K Chan, TR Halfdanarson… - CA: A Cancer …, 2024 - Wiley Online Library
Abstract The American Joint Committee on Cancer (AJCC) staging system for all cancer
sites, including gastroenteropancreatic neuroendocrine tumors (GEP‐NETs), is meant to be …

The tumor microenvironment in neuroendocrine tumors: biology and therapeutic implications

M Cives, E Pelle, D Quaresmini, FM Rizzo… - …, 2019 - karger.com
Neuroendocrine tumors (NETs) include a heterogeneous group of malignancies arising in
the diffuse neuroendocrine system and characterized by indolent growth. Complex …