[HTML][HTML] Naturally-occurring alkaloids of plant origin as potential antimicrobials against antibiotic-resistant infections

B Casciaro, L Mangiardi, F Cappiello, I Romeo… - Molecules, 2020 - mdpi.com
Antibiotic resistance is now considered a worldwide problem that puts public health at risk.
The onset of bacterial strains resistant to conventional antibiotics and the scarcity of new …

Astaxanthin with different configurations: Sources, activity, post modification, and application in foods

J Sun, J Yan, H Dong, K Gao, K Yu, C He… - Current Opinion in Food …, 2023 - Elsevier
Highlights•Different configurations of astaxanthin lead to differences in activity.•Thermal and
catalytic isomerization can be used to prepare other configurational isomers.•Structural …

A comprehensive analytical framework integrating liquid chromatography-tandem mass spectrometry metabolomics with chemometrics for metabolite profiling of …

AM Otify, SA ElBanna, BM Eltanany, L Pont… - Food Research …, 2023 - Elsevier
This study comprehensively characterized the metabolite profiles of six lettuce varieties and
established the correlation between the elucidated profiles and their antivirulence effects. A …

[HTML][HTML] Phytochemical Profile of Antibacterial Agents from Red Betel Leaf (Piper crocatum Ruiz and Pav) against Bacteria in Dental Caries

L Heliawati, S Lestari, U Hasanah, D Ajiati, D Kurnia - Molecules, 2022 - mdpi.com
Based on data from The Global Burden of Disease Study in 2016, dental and oral health
problems, especially dental caries, are a disease experienced by almost half of the world's …

[HTML][HTML] Synthetic and Semisynthetic Compounds as Antibacterials Targeting Virulence Traits in Resistant Strains: A Narrative Updated Review

D Stojković, J Petrović, T Carević, M Soković, K Liaras - Antibiotics, 2023 - mdpi.com
This narrative review paper provides an up-to-date overview of the potential of novel
synthetic and semisynthetic compounds as antibacterials that target virulence traits in …

[HTML][HTML] Antibacterial Activity of the Essential Oil of Piper tuberculatum Jacq. Fruits against Multidrug-Resistant Strains: Inhibition of Efflux Pumps and β-Lactamase

LYS da Silva, CLR Paulo, TF Moura, DS Alves… - Plants, 2023 - mdpi.com
Antimicrobial resistance has become a growing public health concern in recent decades,
demanding a search for new effective treatments. Therefore, this study aimed to elucidate …

[HTML][HTML] Biological activity of selected natural and synthetic terpenoid lactones

AK Surowiak, L Balcerzak, S Lochyński… - International journal of …, 2021 - mdpi.com
Terpenoids with lactone moieties have been indicated to possess high bioactivity. Certain
terpenoid lactones exist in nature, in plants and animals, but they can also be obtained by …

[HTML][HTML] Plumbagin resurrect colistin susceptible against colistin-resistant Pseudomonas aeruginosa in vitro and in vivo

Y Wang, J Kong, X Zhang, Y Liu, Z Huang… - Frontiers in …, 2022 - frontiersin.org
The global emergence and spread of multi-drug resistant (MDR) strains is becoming
increasingly worrisome due to the overuse of broad-spectrum antibiotics. Colistin, the last …

[HTML][HTML] Synthesis and biological evaluation of novel cinnamic acid-based antimicrobials

M Mingoia, C Conte, A Di Rienzo, MP Dimmito… - Pharmaceuticals, 2022 - mdpi.com
The main antimicrobial resistance (AMR) nosocomial strains (ESKAPE pathogens such as
Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter …

A unique high-diversity natural product collection as a reservoir of new therapeutic leads

F Ghirga, D Quaglio, M Mori, S Cammarone… - Organic Chemistry …, 2021 - pubs.rsc.org
Plants represent a rich source of structurally diverse secondary metabolites, which can be
exploited in the development of new clinically important compounds. Indeed, due to their …