Colorectal cancer represents the third most common and the second deadliest type of
cancer for both men and women in the United States claiming over 50000 lives in 2014. The …

MicroRNA (miRNA) are small noncoding RNA molecules that are involved in post-
transcriptional gene silencing. Alterations in miRNA expression are observed in and may …

Cancer is one of main health public problems worldwide. Several factors are involved in
beginning and development of cancer. Genetic and internal/external environmental factors …

Background The mechanism underlying colorectal cancer (CRC) initiation and progression
remains elusive, and overall survival is far from satisfactory. Previous studies have shown …

Epidermal growth factor receptors (EGFR) contribute to colonic tumorigenesis in
experimental models of colon cancer. We previously showed that EGFR was also required …

Background & Aims Inhibitors of the epidermal growth factor receptor (EGFR) are the first-
line therapy for patients with metastatic colorectal tumors without RAS mutations. However …

Colorectal cancer, unlike many other malignancies, may be preventable. Recent studies
have demonstrated an inverse association between nut consumption and incidence of colon …

Inflammatory bowel disease (IBD) is a chronic illness caused by complex interactions
between genetic and environmental factors that propagate inflammation and damage to the …

Colorectal cancer (CRC) is a heterogeneous disease that includes both hereditary and
sporadic types of tumors. Tumor initiation and growth is driven by mutational or epigenetic …

Purpose: Epidermal growth factor receptors (EGFR) are required for tumor promotion by
Western diet. The metalloprotease, ADAM17 activates EGFR by releasing pro-EGFR …