Encouraged by the worldwide success of cisplatin in the field of cancer chemotherapy,
intensive works have been conducted to explore more platinum coordination complexes as …

Platinum-based anticancer drugs dominate the chemotherapy field for several cancers, but
problems such as systemic toxicity and acquired resistance for some primary tumors hamper …

Mitophagy is a selective autophagic process that degrades dysfunctional mitochondria.
Monofunctional platinum (II) complexes are candidates for anticancer drugs with the …

Since the accidental discovery of the anticancer properties of cisplatin more than half a
century ago, significant efforts by the broad scientific community have been and are currently …

Platinum (IV) prodrugs c, c, t-[PtCl 2 (NH 3) 2 (OH)(amlexanox)](MAP) and c, c, t-[PtCl 2 (NH
3) 2 (amlexanox) 2](DAP) were synthesized by reacting amlexanox with oxoplatin and …

Platinum-based anticancer drugs represented by cisplatin play important roles in the
treatment of various solid tumors. However, their applications are largely compromised by …

Platinum-based anticancer agents such as cisplatin and its analogues are widely used for
treating multiple cancers. However, due to the inferior water-solubility, chemoresistance and …

Mounting evidence suggests that impairment of mitochondrial DNA (mtDNA), an important
element in the response of mitochondrial biological function but more susceptible to damage …

Monofunctional Pt (II) complexes represent a class of antitumor agents that may expand the
antitumor spectrum and overcome the drug resistance of the clinically used cisplatin and its …

Iridium( iii ) complexes as mitochondrial topoisomerase inhibitors against cisplatin-resistant cancer
cells - Chemical Communications (RSC Publishing) DOI:10.1039/D1CC02178H Royal Society of …