Benzimidazole-quinoline-based copper complexes: Exploration for their possible antitumor mechanism

J Hu, T Cao, B Yuan, Y Guo, J Zhang, X Zhao, H Hou - Polyhedron, 2022 - Elsevier
In this study, we synthesised and characterised two benzimidazole-quinoline-based copper
complexes, namely,[Cu (btmbq) Br] 2 (1) and [Cu (btmbq) Cl] 2 (2),(btmbq= 3-(1-(1H …

Nuclease-like metalloscissors: Biomimetic candidates for cancer and bacterial and viral infections therapy

M Anjomshoa, B Amirheidari - Coordination Chemistry Reviews, 2022 - Elsevier
Despite the extensive and rapid discovery of modern drugs for treatment of cancer, microbial
infections, and viral illnesses; these diseases are still among major global health concerns …

A trifunctional Pt (II) complex alleviates the NHEJ/HR-related DSBs repairs to evade cisplatin-resistance in NSCLC

X Wang, Y Wang, S Gou, F Chen - Bioorganic Chemistry, 2020 - Elsevier
Cisplatin, a representative of platinum-based drug, is clinically and widely used in the
treatment of various types of malignant cancer. However, its non-selectivity to almost all the …

Azide-mediated unusual in situ transformation of Mannich base to Schiff–Mannich base and isolation of their Cu (ii) complexes: crystal structure, theoretical inspection …

S Mukherjee, S Hansda, S Nandi, T Chakraborty… - Dalton …, 2021 - pubs.rsc.org
A new “end-off” compartmental Mannich ligand (HL1) namely 3-((bis (2-methoxyethyl)
amino) methyl)-5-bromo-2-hydroxybenzaldehyde containing two methoxyethyl pendant …

Bis-N-Heterocyclic Carbene Complexes of Coinage Metals Containing Four Naphthalimide Units: A Structure–Emission Properties Relationship Study

Z Hendi, S Jamali, SMJ Chabok, A Jamjah… - Inorganic …, 2021 - ACS Publications
Naphthalimide derivatives provide highly versatile self-assembled systems and aggregated
forms with fascinating emission properties that make them potential candidates for many …

Synthesis, structure and in vitro anticancer activity of copper (II) and platinum (II) complexes with pyrrol-appended dipicolylamine ligand

X Huang, W Li, Q Wang, L Hu, W Tang, C Gao… - Inorganic Chemistry …, 2024 - Elsevier
Copper complexes exhibit important potential applications as non-platinum based
metallodrugs particularly in the field of anticancer research. In this paper, mononuclear …

A G-quadruplex-binding platinum complex induces cancer mitochondrial dysfunction in vitro and in vivo independently of ROS induction

K Kuang, C Li, F Maksut, D Ghosh, R Vinck, M Wang… - 2023 - chemrxiv.org
G-quadruplex DNA (G4) is a non-canonical structure forming in guanine-rich regions, which
play a vital role in cancer biology and are now being acknowledged in both nuclear and …

DNA interactive and selective anticancer activity studies of copper (II) complexes decorated water‐soluble porphyrin

Q Zhang, B Hou, Y Li, W Zhang… - Applied Organometallic …, 2021 - Wiley Online Library
Cancer is one of the diseases that seriously threaten the health of peoples. As a
representative of metal drugs, cisplatin has considerable promise for the treatment of cancer …

Mitochondria as a Metallo-Drug Target for Therapeutic Purposes

A Erxleben - Targeted Metallo-Drugs, 2023 - taylorfrancis.com
As the cell's power plants, the mitochondria provide the cell with ATP through oxidative
phosphorylation. However, they are also key players in biosynthesis and regulated cell …

Atividade biológica in vitro e in silico de complexos de metais de transição puros e nanoformulados

RC Lino - 2022 - repositorio.ufu.br
O câncer é uma enfermidade que vem acometendo cada vez mais um número maior de
pessoas em todo o Mundo, sendo um dos principais problemas de saúde enfrentados pelos …