Neutrophils play a critical role in the acute inflammatory response and host-defenses
against bacterial infections. Neutropenia, a deficiency of these cells, predisposes to …

Overview. We show the existence of adult human mesenchymal progenitor cells (hMPCs)
that can proliferate, in a cytokine-dependent manner, as individual cells in stirred …

Maintenance of haematopoietic stem cells and differentiation of committed progenitors
occurs in highly specialized niches. The interactions of haematopoietic stem and progenitor …

The α integrin GPIIb is a marker of hematopoietic progenitors. Using a marking strategy
based on Cre-loxP technology to trace the fate of GPIIb-expressing cells, we show that GPIIb …

Physiological interactions between the nervous and immune systems with components of
the local microenvironment are needed to maintain homeostasis throughout the body …

Hematopoiesis is a balance among quiescence, self-renewal, proliferation, and
differentiation, which is believed to be firmly adjusted through interactions between …

OBJECTIVE: Human embryonic stem (ES) cells can be induced to differentiate into
hematopoietic lineages either by stromal cell coculture or by formation of embryoid bodies …

The development of secondary cancers, metastases, requires that a multitude of events are
completed in an ordered and sequential manner. This review focuses on the role of cell …

Integrins play an important role in haematopoietic stem cell (HSC) maintenance in the bone
marrow niche. Here, we demonstrate that Periostin (Postn) via interaction with Integrin-αv …

Mesenchymal stem cells (MSCs) play an important role in the physiology and homeostasis
of the hematopoietic system. Because MSCs generate most of the stromal cells present in …