Self‐renewal and differentiation of stem cells can be the best option for treating intractable
diseases in regenerative medicine, and they occur when these cells reside in a special …

Abstract RUNX1/ETO (RE), the t (8; 21)-derived leukemic transcription factor associated with
acute myeloid leukemia (AML) development, deregulates genes involved in differentiation …

Migratory capacity is a fundamental property of hematopoietic stem and progenitor cells
(HSPCs). This feature is employed in clinical mobilization of HSPCs to the circulation and …

Integrins are transmembrane adhesion receptors that play an important role in
hematopoiesis by facilitating interactions between hematopoietic cells and extracellular …

Despite intensive molecular biology investigations over the past 10 years, and an important
breakthrough on how PML–RARα, the fusion protein resulting from t (15; 17), can alter …

Since the establishment of cell lines derived from human embryonic stem (ES) cells, it has
been speculated that out of such “raw material,” we could some day produce all sorts of …

Real-time cell analysis (RTCA) system based on measurement of electrical microimpedance
has been introduced to monitor adherent cell cultures. We describe its use for real-time …

Chronic myelogenous leukemia (CML) is a hematological malignancy that is characteristic
by as expansion of myeloid cells and their premature release into the circulation. The …

Background Adhesion of cancer cells to extracellular matrix laminin through the integrin
superfamily reportedly induces drug resistance. Heterodimers of integrin α6 (CD49f) with …

Leukocytes rely on dynamic actin-dependent changes in cell shape to pass through blood
vessels, which is fundamental to immune surveillance. Wiskott-Aldrich Syndrome protein …