In vitro proliferation of hematopoietic stem cells (HSCs) is yet an unresolved challenge.
Found in the bone marrow, HSCs can undergo self-renewing cell division and thereby …

Several laboratories have documented the necessity for direct contact of lymphoid and
myeloid leukemic cells with bone marrow stromal cells for optimal survival. Subsequent …

OBJECTIVE AND METHODS: The knowledge of the mechanisms underlying the adhesive
processes that lead to homing and/or mobilization of hematopoietic progenitor cells, and the …

Myelodysplastic syndromes (MDS) represent a heterogeneous group of clonal
hematopoietic stem cell disorders that are preferentially diagnosed in the elderly. Aberrant …

The cultivation of erythroid cells at large scale would have to be performed in suitable
bioreactors which would most likely employ some mode of agitation to ensure optimal mass …

During the last decades, extended characterizations were performed of human full‐term
cord blood (hTCB) cells, but little information is available on human early preterm cord blood …

Interaction of leukemia blasts with the bone marrow extracellular matrix often results in
protection of leukemia cells from chemotherapy and in persistence of the residual disease …

Outside-in integrin signaling regulates cell fate decisions in a variety of cell types, including
hematopoietic stem cells (HSCs). Our earlier published studies showed that interruption of …

Early clinical reports outlining outcomes for primarily pediatric patients undergoing UCB
transplantation point to delayed time to hematopoietic recovery and favorable incidence and …