Cellular hypoxia occurs when the demand for sufficient molecular oxygen needed to
produce the levels of ATP required to perform physiological functions exceeds the vascular …

The extracellular matrix (ECM) is one of the major components of tumors that plays multiple
crucial roles, including mechanical support, modulation of the microenvironment, and a …

Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …

Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-
related deaths. Yet, it remains poorly understood. The continuous evolution of cancer …

Simple Summary Vimentin is an important filamentous protein providing structural and
functional support to the cell. During initial stages of cancer development, vimentin …

Aim Clinical resistance is a complex phenomenon in major human cancers involving
multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular …

The Warburg effect, which originally described increased production of lactate in cancer, is
associated with diverse cellular processes such as angiogenesis, hypoxia, polarization of …

Clear-cell carcinomas (CCCs) are a histological group of highly aggressive malignancies
commonly originating in the kidney and ovary. CCCs are distinguished by aberrant lipid and …

Abstract Hypoxia‐inducible factor 1 (HIF‐1) plays an indispensable role in the hypoxic tumor
microenvironment. Hypoxia and HIF‐1 are involved in multiple aspects of tumor progression …

In the open metabolic system, redox-related signaling requires continuous monitoring and
fine-tuning of the steady-state redox set point. The ongoing oxidative metabolism is a …