An imbalance between estrogen action relative to androgen action at the breast tissue level
results in gynecomastia. Enhancement of aromatization of androgens to estrogens is …

Abstract 17β-hydroxysteroid dehydrogenase 3 deficiency consists of a defect in the last
phase of steroidogenesis, in which androstenedione is converted into testosterone and …

Hypospadias is one of the most common congenital anomalies in the United States,
occurring in approximately 1 in 125 live male births. It is characterized by altered …

β-hydroxysteroid dehydrogenase type 3 (17βHSD-3) deficiency is a rare, but frequently
misdiagnosed autosomal recessive cause of 46, XY disorder of sex development (DSD) …

Gynecomastia is a benign condition in males, characterized by proliferation of glandular
elements resulting in concentric enlargement of one or both breasts. During puberty, there is …

Gynecomastia is a common disorder that generally reflects an increased effective
estrogen/androgen ratio acting on the breast. It is usually idiopathic or related to normal …

Production of appropriate quantities of estrogen in various tissues is essential for human
physiology. A single gene (CYP19), regulated via tissue-specific promoters, encodes the …

Increased extraglandular aromatization has been reported to cause the rare entity of familial
gynecomastia. Recently heterozygous inversions at the p450 aromatase gene promotor …

PURPOSE:: Gynecomastia is a potentially treatment limiting adverse event in men receiving
hormone therapy for prostate cancer. MATERIALS AND METHODS:: In large, randomized …

Five known~ s~ nzymes catalyze the 17~-hydroxyster~ id dehydrugen~ e reaction that
controls the interconversion of estrone and estradiol and of testosterone and …